Methylergometrine maleate

Name: Methylergometrine maleate
Brand: Tocris Bioscience
SKU: 0549

Tocris Bioscience a Bio-Techne Brand

Catalog # 0549

Citations (2)

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Key Product Details

Description:	Active metabolite of methysergide (Cat. No. 1064)
Alternative Names:	Methylergonovine maleate
Chemical Name:	[8β(S)]-9,10-Didehydro-N-[1-(hydroxymethyl)propyl]-6-methylergoline-8-carboxamide maleate
Purity:	≥98% (HPLC)
Molecular Weight:	455.51

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Biological Activity for Methylergometrine maleate

Methylergometrine maleate is an active metabolite of methysergide (Cat. No. 1064); uterotonic agent and oxytocic.

Technical Data for Methylergometrine maleate

M. Wt	455.51
Formula	C₂₀H₂₅N₃O₂.C₄H₄O₄
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	57432-61-8
PubChem ID	5281072
InChi Key	NOFOWWRHEPHDCY-DAUURJMHSA-N
Smiles	OC(=O)\C=C/C(O)=O.[H][C@](CC)(CO)NC(=O)[C@@]1([H])CN(C)[C@]2([H])CC3=CNC4=C3C(=CC=C4)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Methylergometrine maleate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		25

Preparing Stock Solutions for Methylergometrine maleate

The following data is based on the product molecular weight 455.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	8.78 mL	43.91 mL	87.81 mL
1.25 mM	1.76 mL	8.78 mL	17.56 mL
2.5 mM	0.88 mL	4.39 mL	8.78 mL
12.5 mM	0.18 mL	0.88 mL	1.76 mL

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References for Methylergometrine maleate

References are publications that support the biological activity of the product.

Pertz 5-Hydroxytryptamine (5-HT) contracts the guinea-pig isolated iliac artery via 5-HT1-like and 5-HT2 receptors. Naunyn Schmiedebergs Arch.Pharmacol. 1993 PMID: 8133899
MacLennan and Martin Actions of non-peptide ergot alkaloids at 5-HT₁-like and 5-HT₂ receptors mediating vascular smooth muscle contraction. Naunyn Schmiedebergs Arch.Pharmacol. 1990 PMID: 2234096
Muller-Schweinitzer and Tapparelli Methylergometrine, an active metabolite of methysergide. Cephalalgia 1986 PMID: 3698092

Citations for Methylergometrine maleate (2)

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Citations are publications that use Bio-Techne products. Selected citations for Methylergometrine maleate include:

Chan et al. (2015) Ergot Alkaloids (Re)generate New Leads as Antiparasitics. Cell Signal. 9:e0004063
PMID: 26367744
Murray et al. (2011) Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol. 106:925
PMID: 21653728

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