Methysergide maleate

Name: Methysergide maleate
Brand: Tocris Bioscience
SKU: 1064
Price: 264 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 1064

Citations (7)

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Key Product Details

Description:	5-HT₁/5-HT₂ antagonist
Chemical Name:	[8β(S)]-9,10-Didehydro-N-[1-(hydroxymethyl)propyl]-1,6-dimethylergoline-8-carboxamide maleate
Purity:	≥99% (HPLC)
Molecular Weight:	469.54

View Full Technical Details for Methysergide maleate

Biological Activity for Methysergide maleate

Methysergide maleate is a mixed 5-HT₁/5-HT₂ receptor antagonist.

Technical Data for Methysergide maleate

M. Wt	469.54
Formula	C₂₁H₂₇N₃O₂.C₄H₄O₄
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	129-49-7
PubChem ID	5281073
InChi Key	LWYXFDXUMVEZKS-ZVFOLQIPSA-N
Smiles	OC(=O)\C=C/C(O)=O.[H][C@@]12CC3=CN(C)C4=CC=CC(=C34)C1=C[C@H](CN2C)C(=O)N[C@@H](CC)CO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Methysergide maleate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	4.7	10 with gentle warming

Preparing Stock Solutions for Methysergide maleate

The following data is based on the product molecular weight 469.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.30 mL	106.49 mL	212.97 mL
0.5 mM	4.26 mL	21.30 mL	42.59 mL
1 mM	2.13 mL	10.65 mL	21.30 mL
5 mM	0.43 mL	2.13 mL	4.26 mL

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References for Methysergide maleate

References are publications that support the biological activity of the product.

Hoyer VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 1994 PMID: 7938165

Citations for Methysergide maleate (7)

Showing 1 - 7 of 7 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Methysergide maleate include:

Williams et al. (2012) Reduced levels of serotonin 2A receptors underlie resistance of Egr3-deficient mice to locomotor suppression by cloz. Neuropsychopharmacology. 37:2285
PMID: 22692564
Moreno et al. (2011) Maternal influenza viral infection causes schizophrenia-like alterations of 5-HT2A and mGlu2 receptors in the adult offspring. Hypertension. 31:1863
PMID: 21289196
Murray et al. (2011) Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol. 106:925
PMID: 21653728
Murray et al. (2010) Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors. Nat Med. 16:694
PMID: 20512126
Dacks et al. (2009) Serotonin modulates olfactory processing in the antennal lobe of Drosophila. J Neurosci. 23:366
PMID: 19863268
Huang et al. (2009) Autocrine and paracrine roles for ATP and serotonin in mouse taste buds. Neuron. 29:13909
PMID: 19890001
González-Maeso et al. (2007) Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior. J Neurosci. 53:439
PMID: 17270739

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Showing 1 - 7 of 7 citations Showing All

Product Documents for Methysergide maleate

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.