Tocris Bioscience a Bio-Techne Brand
Key Product Details
|Description:||NMDA antagonist; acts at ion channel site|
|Chemical Name:||3,5-Dimethyl-tricyclo[188.8.131.52,7]decan-1-amine hydrochloride|
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Citations for Memantine hydrochloride (17)
Citations are publications that use Bio-Techne products. Selected citations for Memantine hydrochloride include:
Bali et al.
Cognitive enhancer effects of low Mem. doses are facilitated by an alpha7 nicotinic acetylcholine receptor agonist in scopolamine-induced amnesia in rats.
Bouchard-Cannon et al.
Dexras1 is a homeostatic regulator of exercise-dependent proliferation and cell survival in the hippocampal neurogenic niche.
Sachser et al.
Forgetting of long-term memory requires activation of NMDA receptors, L-type voltage-dependent Ca(2+) channels, and calcineurin.
Birnbaum et al.
Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss.
Campbell et al.
Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasia.
Invest Ophthalmol Vis Sci.
Simma et al.
NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells.
Front Cell Neurosci.
He and Bausch
Synaptic plasticity in glutamatergic and GABAergic neurotransmission following chronic Mem. treatment in an in vitro model of limbic epileptogenesis.
Hedegaard et al.
Molecular pharmacology of human NMDA receptors.
Kaufman et al.
Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons.
Cell Death Dis.
Carlson et al.
Pharmacological evidence that D-aspartate activates a current distinct from ionotropic glutamate receptor currents in Aplysia californica.
Puddifoot et al.
Pharmacological characterization of recombinant NR1/NR2A NMDA receptors with truncated and deleted carboxy termini expressed in Xenopus laevis oocytes.
Br J Pharmacol.
Fan and Cooper
Glutamate-induced NFκB activation in the retina.
Proc Natl Acad Sci U S A.
Costa et al.
Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition.
Léveillé et al.
Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors.
Manning et al.
NMDA receptor blockade with Mem. attenuates white matter injury in a rat model of periventricular leukomalacia.
Cell Commun Signal.
Jaekel et al.
Neuroprotection associated with alternative splicing of NMDA receptors in rat cortical neurons.
Rzeski et al.
Glutamate antagonists limit tumor growth.
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Customer Reviews for Memantine hydrochloride (2)
Species: HumanCell Line/Tissue: Stem cell - derived neuronsMemantine was used as a use-dependent blocker of NMDA receptors in nucleated patches pulled from stem-cell-derived dopamine neurons. Application of 0.5 µM memantine induced a significant decrease of NMDA receptors response. Washout for 4-5 minutes commonly returned the response amplitude to control values (see illustration).
Species: RatAssay Type: In VivoWe have been using memantine hydrochloride from Tocris for behavioral pharmacology and in vivo electrophysiology in rats. In electrophysiology experiments, memantine was delivered with microiontophoresis into the close vicinity of the neurons during recording in the rat cerebral cortex. Memantine was successfully applied from glass micropipettes of multi-barrel electrodes with positive constant currents at acidic pH, and it exerted the expected effect on hippocampal neurons (see attached figure of a representative recording).In behavioral experiments, memantine enhanced cognitive function in scopolamine-induced transient amnesia in rats. However, we found that memantine was effective at substantially lower doses compared to most of the publications from other laboratories.It is recommended to always perform an initial experiment for the assessment of the dose-response curve, and not to rely on available literature data regarding suggested suitable doses, since the effect of memantine may substantially differ in different assays or behavioral paradigms.
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