Memantine hydrochloride

Citations are publications that use Bio-Techne products. Selected citations for Memantine hydrochloride include:

• Bali et al. (2019) Cognitive enhancer effects of low Mem. doses are facilitated by an alpha7 nicotinic acetylcholine receptor agonist in scopolamine-induced amnesia in rats. Front Pharmacol. 10:73
  PMID: 30804787
• Bouchard-Cannon et al. (2018) Dexras1 is a homeostatic regulator of exercise-dependent proliferation and cell survival in the hippocampal neurogenic niche. Sci Rep. 8:5294
  PMID: 29593295
• Sachser et al. (2016) Forgetting of long-term memory requires activation of NMDA receptors, L-type voltage-dependent Ca(2+) channels, and calcineurin. Sci Rep. 6:22771
  PMID: 26947131
• Birnbaum et al. (2015) Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss. J Neurosci. 6:e1791
  PMID: 26086964
• Campbell et al. (2015) Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasia. Invest Ophthalmol Vis Sci. 8:425
  PMID: 25565960
• Simma et al. (2014) NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells. Front Cell Neurosci. 12:75
  PMID: 25477292
• He and Bausch (2014) Synaptic plasticity in glutamatergic and GABAergic neurotransmission following chronic Mem. treatment in an in vitro model of limbic epileptogenesis. J Neurosci. 77:379
  PMID: 24184417
• Hedegaard et al. (2012) Molecular pharmacology of human NMDA receptors. Neurochem Int. 61:601
  PMID: 22197913
• Kaufman et al. (2012) Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons. Cell Death Dis. 32:3992
  PMID: 22442066
• Carlson et al. (2012) Pharmacological evidence that D-aspartate activates a current distinct from ionotropic glutamate receptor currents in Aplysia californica. Brain Behav. 2:391
  PMID: 22950043
• Puddifoot et al. (2009) Pharmacological characterization of recombinant NR1/NR2A NMDA receptors with truncated and deleted carboxy termini expressed in Xenopus laevis oocytes. Br J Pharmacol. 156:509
  PMID: 19154422
• Fan and Cooper (2009) Glutamate-induced NFκB activation in the retina. Proc Natl Acad Sci U S A. 50:917
  PMID: 18836176
• Costa et al. (2008) Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition. J Neurosci. 28:8040
  PMID: 18685029
• Léveillé et al. (2008) Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors. FASEB J. 22:4258
  PMID: 18711223
• Manning et al. (2008) NMDA receptor blockade with Mem. attenuates white matter injury in a rat model of periventricular leukomalacia. Cell Commun Signal. 28:6670
  PMID: 18579741
• Jaekel et al. (2006) Neuroprotection associated with alternative splicing of NMDA receptors in rat cortical neurons. Neuropharmacology. 147:622
  PMID: 16314856
• Rzeski et al. (2001) Glutamate antagonists limit tumor growth. FASEB J. 98:6372
  PMID: 11331750

There are no citations that match your criteria.

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• Use-dependent block of NMDA receptors

  Name: Sergiy Sylantyev
  Species: Human
  Cell Line/Tissue: Stem cell - derived neurons
  Memantine was used as a use-dependent blocker of NMDA receptors in nucleated patches pulled from stem-cell-derived dopamine neurons. Application of 0.5 µM memantine induced a significant decrease of NMDA receptors response. Washout for 4-5 minutes commonly returned the response amplitude to control values (see illustration).
  Reference
  

• Memantine hydrochloride in in vivo electrophysiology and in behavioral pharmacology

  Name: Zsolt Bali
  Species: Rat
  Assay Type: In Vivo
  We have been using memantine hydrochloride from Tocris for behavioral pharmacology and in vivo electrophysiology in rats. In electrophysiology experiments, memantine was delivered with microiontophoresis into the close vicinity of the neurons during recording in the rat cerebral cortex. Memantine was successfully applied from glass micropipettes of multi-barrel electrodes with positive constant currents at acidic pH, and it exerted the expected effect on hippocampal neurons (see attached figure of a representative recording).In behavioral experiments, memantine enhanced cognitive function in scopolamine-induced transient amnesia in rats. However, we found that memantine was effective at substantially lower doses compared to most of the publications from other laboratories.
  It is recommended to always perform an initial experiment for the assessment of the dose-response curve, and not to rely on available literature data regarding suggested suitable doses, since the effect of memantine may substantially differ in different assays or behavioral paradigms.
  PMID: 30804787 Reference
  

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