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Memantine hydrochloride

NMDA Receptor Antagonists Small Molecule

Key Product Details

Description: NMDA antagonist; acts at ion channel site
Chemical Name: 3,5-Dimethyl-tricyclo[3.3.1.13,7]decan-1-amine hydrochloride

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  • Use-dependent block of NMDA receptors
    Name: Sergiy Sylantyev | 15th Oct 2020
    Species: Human
    Cell Line/Tissue: Stem cell - derived neurons
    Memantine was used as a use-dependent blocker of NMDA receptors in nucleated patches pulled from stem-cell-derived dopamine neurons. Application of 0.5 µM memantine induced a significant decrease of NMDA receptors response. Washout for 4-5 minutes commonly returned the response amplitude to control values (see illustration).
    Use-dependent block of NMDA receptors Serum 0773
  • Memantine hydrochloride in in vivo electrophysiology and in behavioral pharmacology
    Name: Zsolt Bali | 1st Mar 2019
    Species: Rat
    Assay Type: In Vivo
    We have been using memantine hydrochloride from Tocris for behavioral pharmacology and in vivo electrophysiology in rats. In electrophysiology experiments, memantine was delivered with microiontophoresis into the close vicinity of the neurons during recording in the rat cerebral cortex. Memantine was successfully applied from glass micropipettes of multi-barrel electrodes with positive constant currents at acidic pH, and it exerted the expected effect on hippocampal neurons (see attached figure of a representative recording).In behavioral experiments, memantine enhanced cognitive function in scopolamine-induced transient amnesia in rats. However, we found that memantine was effective at substantially lower doses compared to most of the publications from other laboratories.
    It is recommended to always perform an initial experiment for the assessment of the dose-response curve, and not to rely on available literature data regarding suggested suitable doses, since the effect of memantine may substantially differ in different assays or behavioral paradigms.
    Memantine hydrochloride in in vivo electrophysiology and in behavioral pharmacology Serum 0773

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