BDNF (human)
Tocris Bioscience, part of Bio-Techne | Catalog # 2837
Activates TrkB and p75 receptors
Product Description
BDNF (human) is a member of the neurotrophin growth factor family that binds and activates TrkB and p75 neurotrophin receptors. BDNF enhances the survival, growth and differentiation of neurons. BDNF expression is altered in neurodegenerative disorders such as Parkinson's and Alzheimer's disease. In an animal model of Huntington's disease, BDNF administration or overexpression rescues the disease phenotype.Product Specifications
Molecular Weight
26984.00
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
218441-99-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
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Background References
References are publications that support the biological activity of the product.
- Zuccato Progressive loss of BDNF in a mouse model of Huntington's disease and rescue by BDNF delivery. Pharmacol.Res. 2005 PMID: 15967378
- Evans and Barker Neurotrophic factors as a therapeutic target for Parkinson's disease. Expert Opin.Ther.Targets 2008 PMID: 18348680
- Wang The when and where of BDNF and the antidepressant response. Biol.Psychiat. 2008 PMID: 18329441
- Lipsky and Marini Brain-derived neurotrophic factor in neuronal survival and behavior-related plasticity. Ann.N.Y.Acad.Sci. 2007 PMID: 18077569
Product Specific Notices for BDNF (human)
For research use only
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