M8 B hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 5324
Potent and selective TRPM8 channel blocker
Product Description
M8 B hydrochloride is a potent and selective TRPM8 channel blocker. Blocks cold- and icilin-induced TRPM8 activation in vitro (IC50 values are 7.8 and 26.9 nM respectively). Exhibits no effect at other TRP channels (IC50 > 20 μM). Reduces body temperature in vivo.Product Specifications
Molecular Weight
432.96
Formula
C22H24N2O3S.HCl
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride
CAS Number
883976-12-3
PubChem ID
69316632
InChI Key
FMQJBHACRTZLME-UHFFFAOYSA-N
SMILES
COC1=C(OCC2=CC=CC=C2)C=CC(CN(CCN)C(C3=CC=CS3)=O)=C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 4.33 | 10 with sonication | |
| DMSO | 43.3 | 100 |
Preparing Stock Solutions
for M8 B hydrochloride
The following data is based on the product molecular weight 432.96
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.31 mL | 11.55 mL | 23.10 mL |
| 5 mM | 0.46 mL | 2.31 mL | 4.62 mL |
| 10 mM | 0.23 mL | 1.15 mL | 2.31 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Almeida Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. J.Neurosci. 2012 PMID: 22323721
Product Specific Notices for M8 B hydrochloride
For research use only
Loading...
Loading...