M40

Tocris Bioscience, part of Bio-Techne | Catalog # 3425

COA / SDS

Potent, non-selective galanin receptor antagonist

Key Product Details

Description:	Potent, non-selective galanin receptor antagonist
Alternative Names:	Galanin (1-13)-Pro-Pro-(Ala-Leu-)₂Ala amide
Purity:	≥95% (HPLC)
Molecular Weight:	1981.33

View Full Technical Details for M40

Technical Data
Citations

Biological Activity for M40

M40 is a potent, non-selective galanin receptor antagonist (K_i values are 1.82 and 5.1 nM at GAL₁ and GAL₂ respectively) that inhibits galanin (1-29) (Cat. No. 2696) binding in rat brain in vitro (IC₅₀ = 3 - 15 nM). Attenuates the antidepressant effects of fluoxetine (Cat. No. 0927) and blocks galanin-induced food intake in vivo. Also exhibits weak partial agonist activity at peripheral GAL₂ receptors at doses > 100 nM.

Technical Data for M40

M. Wt	1981.33
Formula	C₉₄H₁₄₅N₂₃O₂₄
Single Letter Sequence	GWTLNSAGYLLGPPPALALA (Modifications: Ala-20 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	143896-17-7
PubChem ID	16133821
InChi Key	OSGCBUDLRBUEGW-JZCUZNMGSA-N
Smiles	[H]NCC(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for M40

Solubility

Soluble to 1mg/ml in water

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References for M40

References are publications that support the biological activity of the product.

Yuan Gastric effects of galanin and its interaction with leptin on brainstem neuronal activity. J.Pharm.Exp.Ther.
Lu A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus. Proc.Natl.Acad.Sci.USA
Bartfai Galanin-receptor ligand M40 peptide distinguishes between putative galanin-receptor subtypes. Proc.Natl.Acad.Sci.USA

M40

Tocris Bioscience, part of Bio-Techne | Catalog # 3425

Key Product Details

Biological Activity for M40

Technical Data for M40

Solubility for M40

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for M40

Product Documents for M40

COA

Certificate of Analysis

SDS

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