LY 456236 hydrochloride

Name: LY 456236 hydrochloride
Brand: Tocris Bioscience
SKU: 2390
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2390

(1)

Citations (7)

COA / SDS

Selective mGlu1 antagonist

Key Product Details

Description:	Selective mGlu₁ antagonist
Alternative Names:	MPMQ hydrochloride
Chemical Name:	6-Methoxy-N-(4-methoxyphenyl)-4-quinazolinamine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	317.77

View Full Technical Details for LY 456236 hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for LY 456236 hydrochloride

LY 456236 hydrochloride is a selective mGlu₁ receptor antagonist (IC₅₀ values are 143 nM and > 10 μM for mGlu₁ and mGlu₅ receptors respectively). Reduces hyperalgesic behavior induced by formalin in both mouse and rat with ED₅₀ values of 28 and 16.3 mg/kg respectively.

Technical Data for LY 456236 hydrochloride

M. Wt	317.77
Formula	C₁₆H₁₅N₃O₂.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	338736-46-2
PubChem ID	9926998
InChi Key	AVKFOWUSTVWZQN-UHFFFAOYSA-N
Smiles	Cl.COC1=CC=C(NC2=C3C=C(OC)C=CC3=NC=N2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LY 456236 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	6.36	20

Preparing Stock Solutions for LY 456236 hydrochloride

The following data is based on the product molecular weight 317.77.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	15.73 mL	78.67 mL	157.35 mL
1 mM	3.15 mL	15.73 mL	31.47 mL
2 mM	1.57 mL	7.87 mL	15.73 mL
10 mM	0.31 mL	1.57 mL	3.15 mL

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References for LY 456236 hydrochloride

References are publications that support the biological activity of the product.

Bertorelli Selective blockade of metabotropic glutamate subtype mGluR1 receptors induce anti-nociceptive effects. Neuropharmacology
Shannon Anticonvulsant effects of LY456236, a selective mGlu1 receptor antagonist. Neuropharmacology 2005 PMID: 16011839