Lisuride maleate
Tocris Bioscience, part of Bio-Techne | Catalog # 4052
Dopamine agonist; antiparkinson's agent
Key Product Details
Description
Dopamine agonist; antiparkinson's agent
Product Description
Lisuride maleate is a dopamine receptor agonist and anti-Parkinson's agent. Displays high affinity for D2, D3 and D4 receptors along with 5-HT1A. Exhibits some 5-HT2B receptor antagonist properties. Decreases prolactin release; reduces inflammatory mediators such as TNF-α and IL6. Exhibits anticonvulsive effects. Acts similar to bromocriptine (Cat. No. 0427).Product Specifications
Molecular Weight
454.52
Formula
C20H26N4O.C4H4O4
Storage
Store at RT
Purity
≥99% (HPLC)
Chemical Name
N'-[(8α)-9,10-Didehydro-6-methylergolin-8-yl]-N,N-diethylurea maleate
CAS Number
19875-60-6
PubChem ID
5282421
InChI Key
CVQFAMQDTWVJSV-BAXNFHPCSA-N
SMILES
OC(/C=C\C(O)=O)=O.[H][C@@]1(C2)C(C3=C4C2=CNC4=CC=C3)=C[C@H](NC(N(CC)CC)=O)CN1C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.66 | 100 |
Preparing Stock Solutions
for Lisuride maleate
The following data is based on the product molecular weight 454.52
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.20 mL | 11.00 mL | 22.00 mL |
| 5 mM | 0.44 mL | 2.20 mL | 4.40 mL |
| 10 mM | 0.22 mL | 1.10 mL | 2.20 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Zweckberger Anticonvulsive effects of the DA agonist lisuride maleate after experimental traumatic brain injury. Neurosci.Lett. 2010 PMID: 20056133
- Woitalla Transdermal lisuride delivery in the treatment of Parkinson's disease. J.Neural Transm.
- Hofmann Lisuride, a DA receptor agonist with 5-HT2B receptor antagonist properties: absence of cardiac valvulopathy adverse drug reaction reports supports the concept of a crucial role for 5-HT2B receptor agonism in cardiac valvular fibrosis Clin.Neuropharmacol. 2006 PMID: 16614540
Product Specific Notices for Lisuride maleate
For research use only
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