Bromocriptine mesylate

Name: Bromocriptine mesylate
Brand: Tocris Bioscience
SKU: 0427
Price: 146 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 0427

Citations (3)

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Key Product Details

Description:	D₂-like agonist (D₂>D₃>D₄)
Chemical Name:	(5'a)-2-Bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)ergotaman-3',6',18-trione mesylate
Purity:	≥98% (HPLC)
Molecular Weight:	750.7

View Full Technical Details for Bromocriptine mesylate

Biological Activity for Bromocriptine mesylate

Bromocriptine mesylate is a selective D₃ and D₂ dopamine receptor agonist (K_i values are ~ 5 nM and ~ 8 nM respectively). Activates both isoforms of D₂ receptor (EC₅₀ values are 0.10-0.12 nM and 4.4 nM for D_2L and D_2S receptors, respectively. Bromocriptine shows anti-Aβ effects that are increased in combination with Cromolyn (Cat. No. 6424) and Topiramate (Cat. No. 3620). Also lowers glucose and increases insulin sensitivity in vivo.

Compound Libraries for Bromocriptine mesylate

Bromocriptine mesylate is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Bromocriptine mesylate

M. Wt	750.7
Formula	C₃₂H₄₀BrN₅O₅.CH₃SO₃H
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	22260-51-1
PubChem ID	31100
InChi Key	NOJMTMIRQRDZMT-GSPXQYRGSA-N
Smiles	[H][C@]4([C@@](N[C@]([C@H](C)C)5C(N([C@@]([H])(CC(C)C)C(N(CCC7)[C@@]76[H])=O)[C@@]6(O)O5)=O)=O)CN([C@](C3=C4)([H])CC1=C(Br)NC2=C1C3=CC=C2)C.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Bromocriptine mesylate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	75.07	100

Preparing Stock Solutions for Bromocriptine mesylate

The following data is based on the product molecular weight 750.7.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.33 mL	6.66 mL	13.32 mL
5 mM	0.27 mL	1.33 mL	2.66 mL
10 mM	0.13 mL	0.67 mL	1.33 mL
50 mM	0.03 mL	0.13 mL	0.27 mL

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References for Bromocriptine mesylate

References are publications that support the biological activity of the product.

Tavares Dopamine D2 receptor agonist, bromocriptine, remodels adipose tissue dopaminergic signalling and upregulates catabolic pathways, improving metabolic profile in type 2 diabetes. Mol.Metab. 2021 PMID: 33933677
Kondo iPSC-based compound screening and in vitro trials identify a synergistic anti-amyloid β combination for Alzheimer's disease. Cell Rep. 2017 PMID: 29166618
Seeman and Van Tol DA receptor pharmacology. TiPS 1994 PMID: 7940991
Aubner Bromocriptine produces decreases in cocaine self-administration in the rat. Neuropsychopharmacology 1990 PMID: 2317262
Lieberman and Goldstein Bromocriptine in Parkinson disease. Pharmacol.Rev. 1985 PMID: 3901046
Traub The effects of chronic bromocri. treatment on behaviour and DA receptor binding in the rat striatum. Eur.J.Pharmacol. 1985 PMID: 3936723

Citations for Bromocriptine mesylate (3)

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Citations are publications that use Bio-Techne products. Selected citations for Bromocriptine mesylate include:

Pedersen et al. (2021) A novel luminescence-based-β-arrestin recruitment assay for unmodified receptors. J Biol Chem. 296:100503
PMID: 33684444
Liberante et al. (2016) Identification and validation of the DA agonist bromocri. as a novel therapy for high-risk myelodysplastic syndromes and secondary acute myeloid leukemia. Oncotarget. 7:6609
PMID: 26735888
Jia et al. (2013) Age-dependent regulation of synaptic connections by DA D2 receptors. Nat Neurosci. 16:1627
PMID: 24121738

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Product Documents for Bromocriptine mesylate

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.