L-Glutamic acid

Name: L-Glutamic acid
Brand: Tocris Bioscience
SKU: 0218
Rating: 5 (2 reviews)

Catalog # 0218

Citations (8)

(2)

COA / SDS

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Key Product Details

Description:	Endogenous, non-selective glutamate receptor agonist
Chemical Name:	(S)-1-Aminopropane-1,3-dicarboxylic acid
Molecular Weight:	147.13

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Biological Activity

L-Glutamic acid is a the predominant excitatory transmitter in the mammalian central nervous system. L-Glutamic acid acts at ionotropic and metabotropic glutamate receptors.

MNI-caged-L-glutamate (Cat. No. 1490) also available.

Technical Data

M. Wt	147.13
Formula	C₅H₉NO₄
Storage	Store at RT
CAS Number	56-86-0
PubChem ID	33032
InChi Key	WHUUTDBJXJRKMK-VKHMYHEASA-N
Smiles	[H][C@@](CCC(O)=O)(N)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1eq. NaOH		100

Preparing Stock Solutions

The following data is based on the product molecular weight 147.13.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	6.80 mL	33.98 mL	67.97 mL
5 mM	1.36 mL	6.80 mL	13.59 mL
10 mM	0.68 mL	3.40 mL	6.80 mL
50 mM	0.14 mL	0.68 mL	1.36 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Yang and Stockwell Ferroptosis: Death by lipid peroxidation. Trends Cell Biol. 2016 PMID: 26653790
Monaghan The excitatory amino acid receptors: their classes, pharmacology and distinct properties in the function of the central nervous system. Annu.Rev.Pharmacol.Toxicol. 1989 PMID: 2543272
Watkins and Evans Excitatory amino acid transmitters. Annu.Rev.Pharmacol.Toxicol. 1981 PMID: 6112965

Citations for L-Glutamic acid (8)

Showing 1 - 8 of 8 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for L-Glutamic acid include:

Falcucci et al. (2019) Novel positive allosteric modulators of glutamate transport have neuroprotective properties in an in vitro excitotoxic model. ACS Chem Neurosci. 10:3437
PMID: 31257852
Schitine et al. (2015) Functional plasticity of GAT-3 in avian Müller cells is regulated by neurons via a glutamatergic input. J Neurosci. 82:42
PMID: 25700791
Moreno et al. (2012) Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A�mGlu2) receptor heteromerization and its psychoactive behavioral function. J Biol Chem. 287:44301
PMID: 23129762
Tallarida et al. (2012) Glutamate carboxypeptidase II (GCPII) inhibitor displays anti-glutamate and anti-cocaine effects in an invertebrate assay. Amino Acids. 42:2521
PMID: 21850438
Owaisat et al. (2012) In vivo comparison of harmine efficacy against psychostimulants: preferential inhibition of the cocaine response through a glutamatergic mechanism. Neurosci Lett. 525:12
PMID: 22877698
Moreno et al. (2011) Maternal influenza viral infection causes schizophrenia-like alterations of 5-HT2A and mGlu2 receptors in the adult offspring. J Neurosci. 31:1863
PMID: 21289196
Galici et al. (2006) Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice. J Pharmacol Exp Ther. 318:173
PMID: 16608916
Calò et al. (2005) Interactions between ephrin-B and metabotropic glutamate 1 receptors in brain tissue and cultured neurons. J Neurosci. 25:2245
PMID: 15745950

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Showing 1 - 8 of 8 citations Showing All

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Neuron glia culture

Name: Anonymous

Species: Mouse

Assay Type: In Vitro

Cell Line/Tissue: Mixed neuron-glia

L-glutamate (10 or 100μM)

Incubate for 24h

PMID: 31257852
works good

Name: Anonymous

Species: Rat

Assay Type: In Vitro

Cell Line/Tissue: Sprague-Dawley rats primary neuronal

10 μM L-Glutamic acid for 2 hours

PMID: 31291571 Reference

There are no reviews that match your criteria.