L-690,488

Name: L-690,488
Brand: Tocris Bioscience
SKU: 0682

Catalog # 0682

Citations (1)

COA / SDS

Discontinued Product

0682 has been discontinued. View all Inositol Lipid Inhibitors products.

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Key Product Details

Description:	Cell permeable prodrug of the IMPase inhibitor L-690,330 (Cat. No. 0681)
Chemical Name:	1-[(4-Hydroxyphenoxy)ethylidene]bis[phosphinylidynebis(oxymethylene)]-2,2-dimethylpropanoate
Purity:	≥98% (HPLC)
Molecular Weight:	754.7

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Biological Activity

L-690,488 is a cell-permeable prodrug of the potent inositol monophosphatase inhibitor L-690,330 (Cat. No. 0681); penetrates cells more effectively than its metabolite.

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Technical Data

M. Wt	754.7
Formula	C₃₂H₅₂O₁₆P₂
Storage	Store at -80°C
Purity	≥98% (HPLC)
CAS Number	142523-14-6
PubChem ID	5132514
InChi Key	LOTSPVPQHAUHCE-UHFFFAOYSA-N
Smiles	OC1=CC=C(OC(P(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)(C)P(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	75.47	100
	DMSO	75.47	100

Preparing Stock Solutions

The following data is based on the product molecular weight 754.7.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.33 mL	6.63 mL	13.25 mL
5 mM	0.27 mL	1.33 mL	2.65 mL
10 mM	0.13 mL	0.66 mL	1.33 mL
50 mM	0.03 mL	0.13 mL	0.27 mL

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References

References are publications that support the biological activity of the product.

Chen Stimulatory effect of Li on glucose transport in rat adipocytes is not mediated by elevation of IP₁. Am.J.Physiol. 1998 PMID: 9688629
Atack Effects of L-690,488, a prodrug of the bisphosphonate inositol monophosphatase inhibitor L-690,330, on phosphatidylinositol cycle markers. J.Pharmacol.Exp.Ther. 1994 PMID: 8035344

Citations for L-690,488 (1)

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Citations are publications that use Bio-Techne products. Selected citations for L-690,488 include:

Harding et al. (2013) LtpD is a novel Legionella pneumophila effector that binds phosphatidylinositol 3-phosphate and inositol monophosphatase IMPA1. Mol Cancer. 81:4261
PMID: 24002062

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