L-690,330
Tocris Bioscience, part of Bio-Techne | Catalog # 0681
Inositol monophosphatase inhibitor
Key Product Details
Description
Inositol monophosphatase inhibitor
Product Description
L-690,330 is a potent inhibitor of inositol monophophatase; stable to hydrolysis. Induces autophagy in COS-7 cells independently of mTOR inhibition.Licensing Information
Sold with the permission of Merck Sharp and Dohme Ltd.Product Specifications
Molecular Weight
298.13
Formula
C8H12O8P2
Storage
Store at RT
Chemical Name
[1-(4-Hydroxyphenoxy)ethylidene]bisphosphonic acid
CAS Number
142523-38-4
PubChem ID
132449
InChI Key
JKOCAAWWDVHWKB-UHFFFAOYSA-N
SMILES
CC(OC1=CC=C(O)C=C1)(P(O)(O)=O)P(O)(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 5.96 | 20 |
Preparing Stock Solutions
for L-690,330
The following data is based on the product molecular weight 298.13
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 16.77 mL | 83.86 mL | 167.71 mL |
| 1 mM | 3.35 mL | 16.77 mL | 33.54 mL |
| 2 mM | 1.68 mL | 8.39 mL | 16.77 mL |
| 10 mM | 0.34 mL | 1.68 mL | 3.35 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Sarkar Li induces autophagy by inhibiting inositol monophosphatase. J.Cell.Biol. 2005 PMID: 16186256
- Atack Effects of L-690,488, a pro-drug of the bisphosphonate inisotol monophosphatase inhibitor L-690,330, on phosphatidylinisotol cycle markers. J.Pharmacol.Exp.Ther. 1994 PMID: 8035344
- Fleming Chemical modulators of autophagy as biological probes and potential therapeutics. Nat.Chem.Biol. 2011 PMID: 21164513
- Atack In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330. J.Neurochem. 1993 PMID: 8380439
Product Specific Notices for L-690,330
For research use only
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