L-690,330

Name: L-690,330
Brand: Tocris Bioscience
SKU: 0681
Price: 210 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 0681

Citations (6)

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Key Product Details

Description:	Inositol monophosphatase inhibitor
Chemical Name:	[1-(4-Hydroxyphenoxy)ethylidene]bisphosphonic acid
Molecular Weight:	298.13

View Full Technical Details for L-690,330

Biological Activity for L-690,330

L-690,330 is a potent inhibitor of inositol monophophatase; stable to hydrolysis. Induces autophagy in COS-7 cells independently of mTOR inhibition.

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Technical Data for L-690,330

M. Wt	298.13
Formula	C₈H₁₂O₈P₂
Storage	Store at RT
CAS Number	142523-38-4
PubChem ID	132449
InChi Key	JKOCAAWWDVHWKB-UHFFFAOYSA-N
Smiles	CC(OC1=CC=C(O)C=C1)(P(O)(O)=O)P(O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L-690,330

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	5.96	20

Preparing Stock Solutions for L-690,330

The following data is based on the product molecular weight 298.13.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	16.77 mL	83.86 mL	167.71 mL
1 mM	3.35 mL	16.77 mL	33.54 mL
2 mM	1.68 mL	8.39 mL	16.77 mL
10 mM	0.34 mL	1.68 mL	3.35 mL

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References for L-690,330

References are publications that support the biological activity of the product.

Fleming Chemical modulators of autophagy as biological probes and potential therapeutics. Nat.Chem.Biol. 2011 PMID: 21164513
Sarkar Li induces autophagy by inhibiting inositol monophosphatase. J.Cell.Biol. 2005 PMID: 16186256
Atack Effects of L-690,488, a pro-drug of the bisphosphonate inisotol monophosphatase inhibitor L-690,330, on phosphatidylinisotol cycle markers. J.Pharmacol.Exp.Ther. 1994 PMID: 8035344
Atack In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330. J.Neurochem. 1993 PMID: 8380439

Citations for L-690,330 (6)

Showing 1 - 6 of 6 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for L-690,330 include:

Harding et al. (2013) LtpD is a novel Legionella pneumophila effector that binds phosphatidylinositol 3-phosphate and inositol monophosphatase IMPA1. Infect Immun. 81:4261
PMID: 24002062
Meyer et al. (2011) Inhibition of inositol monophosphatase by Li chloride induces selective macrophage apoptosis in atherosclerotic plaques. Br J Pharmacol. 162:1410
PMID: 21138421
Sarkar et al. (2008) A rational mechanism for combination treatment of Huntington's disease using Li and rapamycin. J Cell Biol. 17:170
PMID: 17921520
Criollo et al. (2007) Regulation of autophagy by the inositol trisphosphate receptor. Cell Death Differ. 14:1029
PMID: 17256008
Sarkar et al. (2005) Li induces autophagy by inhibiting inositol monophosphatase. Infect Immun. 170:1101
PMID: 16186256
Westfall et al. (2003) Wnt-5/pipetail functions in vertebrate axis formation as a negative regulator of Wnt/beta-catenin activity. J Cell Biol. 162:889
PMID: 12952939

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