K34c
Tocris Bioscience, part of Bio-Techne | Catalog # 5114
Potent and selective α5β1 integrin inhibitor
Key Product Details
Description
Potent and selective α5β1 integrin inhibitor
Product Description
K34c is a potent and selective α5β1 integrin inhibitor (IC50 = 3.1 nM). K34c inhibits cell survival and migration, inhibits p53-dependent senescence induced by Temozolomide (Cat. No. 2706) or Ellipticine (Cat. No. 3357) and promotes apoptosis in U87MG cells. K34c also prevents TGFβ-induced infiltration in vivo and reduces cell adhesion on fibronectin.Product Specifications
Molecular Weight
447.53
Formula
C26H29N3O4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-(2,6-Dimethylbenzoyl)-O-[3-(2-pyridinylamino)propyl]-L-tyrosine
CAS Number
939769-93-4
PubChem ID
16663328
InChI Key
VLNHAQFIBARCQP-UHFFFAOYSA-N
SMILES
O=C(C3=C(C)C=CC=C3C)N[C@H](C(O)=O)CC(C=C2)=CC=C2OCCCNC1=CC=CC=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.75 | 100 | |
| Ethanol | 44.75 | 100 |
Preparing Stock Solutions
for K34c
The following data is based on the product molecular weight 447.53
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.23 mL | 11.17 mL | 22.34 mL |
| 5 mM | 0.45 mL | 2.23 mL | 4.47 mL |
| 10 mM | 0.22 mL | 1.12 mL | 2.23 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.45 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kuonen TGF-β, fibronectin and integrin α5β1 promote invasion in basal cell carcinoma. J.Invest.Dermatol. 2018 PMID: 29758283
- Martinkova α5β1 integrin antagonists reduce chemotherapy-induced premature senescence and facilitate apoptosis in human glioblastoma cells. Int.J.Cancer 2010 PMID: 20099278
- Renner Expression/activation of α5β1 integrin is linked to the β-catenin signaling pathway to drive migration in glioma cells. Oncotarget 2016 PMID: 27613837
- Heckmann Probing integrin selectivity: rational design of highly active and selective ligands for the α5β1 and αvβ3 integrin receptor. Angew.Chem.Int.Ed.Engl 2007 PMID: 17394271
Product Specific Notices for K34c
For research use only
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