JNJ 5207852 dihydrochloride

Name: JNJ 5207852 dihydrochloride
Brand: Tocris Bioscience
SKU: 4020

Catalog # 4020 | Tocris Bioscience a Bio-Techne Brand

COA / SDS

High affinity H3 antagonist

Key Product Details

Description:	High affinity H₃ antagonist
Chemical Name:	1-[3-[4-(1-Piperidinylmethyl)phenoxy]propyl]piperidine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	389.4

View Full Technical Details for JNJ 5207852 dihydrochloride

Technical Data
Citations / Reviews

Biological Activity for JNJ 5207852 dihydrochloride

JNJ 5207852 dihydrochloride is a high affinity histamine H₃ receptor neutral antagonist (pK_i values are 8.9 and 9.2 in rat and human respectively). Brain penetrant and orally active. Has 3- and 100-fold higher affinity than thioperamide (Cat. No. 0644) for rat and human H₃ receptors respectively. Suppresses slow-wave sleep; exhibits wake-promoting effects in rodent arousal models.

Licensing Information

Sold with the permission of Ortho-McNeil-Janssen Pharmaceuticals, Inc.

Technical Data for JNJ 5207852 dihydrochloride

M. Wt	389.4
Formula	C₂₀H₃₂N₂O.2HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	1782228-76-5
PubChem ID	90488903
InChi Key	RLLXSVVZCGBIJR-UHFFFAOYSA-N
Smiles	C1(CN2CCCCC2)=CC=C(OCCCN3CCCCC3)C=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JNJ 5207852 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	19.47	50
	DMSO	7.79	20 with gentle warming

Preparing Stock Solutions for JNJ 5207852 dihydrochloride

The following data is based on the product molecular weight 389.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.14 mL	25.68 mL	51.36 mL
2.5 mM	1.03 mL	5.14 mL	10.27 mL
5 mM	0.51 mL	2.57 mL	5.14 mL
25 mM	0.10 mL	0.51 mL	1.03 mL

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References for JNJ 5207852 dihydrochloride

References are publications that support the biological activity of the product.

Le Correlation between ex vivo receptor occupancy and wake-promoting activity of selective H₃ receptor antagonists. J.Pharmacol.Exp.Ther. 2008 PMID: 18305012
Jia Effects of histamine H₃ antagonists and donep. on learning and mnemonic deficits induced by pentylenetetrazol kindling in weanling mice. Neuropharmacology 2005 PMID: 16310812
Barbier Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H₃ antagonist. Br.J.Pharmacol. 2004 PMID: 15466448

Citations for JNJ 5207852 dihydrochloride

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