JNJ 39758979 dihydrochloride

Name: JNJ 39758979 dihydrochloride
Brand: Tocris Bioscience
SKU: 6279

Tocris Bioscience, part of Bio-Techne | Catalog # 6279

COA / SDS

High affinity and selective histamine H4 antagonist; orally bioavailable

Key Product Details

Description:	High affinity and selective histamine H₄ antagonist; orally bioavailable
Chemical Name:	4-[(3R)-3-Amino-1-pyrrolidinyl]-6-(1-methylethyl)-2-pyridinamine dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	294.22

View Full Technical Details for JNJ 39758979 dihydrochloride

Technical Data
Citations

Biological Activity for JNJ 39758979 dihydrochloride

JNJ 39758979 dihydrochloride is a high affinity and selective histamine H₄ antagonist (K_i = 12.5 nM). Exhibits >80-fold selectivity for H₄ over other histamine receptors and no significant activity at a range of other targets. Inhibits histamine-induced eosinophil shape change in whole blood in vitro and ovalbumin-induced inflammation in ovalbumin-sensitized mice in vivo. Orally bioavailable.

Licensing Information

Sold with the permission of Janssen Pharmaceutica N.V.

Compound Libraries for JNJ 39758979 dihydrochloride

JNJ 39758979 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for JNJ 39758979 dihydrochloride

M. Wt	294.22
Formula	C₁₁H₁₉N₅.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
PubChem ID	129628806
InChi Key	KXPWYAVIFCXPRW-YCBDHFTFSA-N
Smiles	CC(C1=CC(N2CC[C@H](C2)N)=NC(N)=N1)C.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JNJ 39758979 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	22.13	100
	DMSO	22.13	100

Preparing Stock Solutions for JNJ 39758979 dihydrochloride

The following data is based on the product molecular weight 294.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.40 mL	16.99 mL	33.99 mL
5 mM	0.68 mL	3.40 mL	6.80 mL
10 mM	0.34 mL	1.70 mL	3.40 mL
50 mM	0.07 mL	0.34 mL	0.68 mL

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References for JNJ 39758979 dihydrochloride

References are publications that support the biological activity of the product.

Thurmond Clinical and preclinical characterization of the histamine H₄ receptor antagonist JNJ-39758979. J.Pharmacol.Exp.Ther. 2014 PMID: 24549371