JNJ 39758979 dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 6279
High affinity and selective histamine H4 antagonist; orally bioavailable
Key Product Details
Description
High affinity and selective histamine H4 antagonist; orally bioavailable
Product Description
JNJ 39758979 dihydrochloride is a high affinity and selective histamine H4 antagonist (Ki = 12.5 nM). Exhibits >80-fold selectivity for H4 over other histamine receptors and no significant activity at a range of other targets. Inhibits histamine-induced eosinophil shape change in whole blood in vitro and ovalbumin-induced inflammation in ovalbumin-sensitized mice in vivo. Orally bioavailable.Licensing Information
Sold with the permission of Janssen Pharmaceutica N.V.Product Specifications
Molecular Weight
294.22
Formula
C11H19N5.2HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
4-[(3R)-3-Amino-1-pyrrolidinyl]-6-(1-methylethyl)-2-pyridinamine dihydrochloride
PubChem ID
129628806
InChI Key
KXPWYAVIFCXPRW-YCBDHFTFSA-N
SMILES
CC(C1=CC(N2CC[C@H](C2)N)=NC(N)=N1)C.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 22.13 | 100 | |
| DMSO | 22.13 | 100 |
Preparing Stock Solutions
for JNJ 39758979 dihydrochloride
The following data is based on the product molecular weight 294.22
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.40 mL | 16.99 mL | 33.99 mL |
| 5 mM | 0.68 mL | 3.40 mL | 6.80 mL |
| 10 mM | 0.34 mL | 1.70 mL | 3.40 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.68 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Thurmond Clinical and preclinical characterization of the histamine H4 receptor antagonist JNJ-39758979. J.Pharmacol.Exp.Ther. 2014 PMID: 24549371
Product Specific Notices for JNJ 39758979 dihydrochloride
For research use only
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