Highly potent, mGlu1-selective non-competitive antagonist
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Key Product Details
Description: | Highly potent, mGlu1-selective non-competitive antagonist |
Chemical Name: | (3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone |
Purity: | ≥98% (HPLC) |
Molecular Weight: | 325.41 |
Citations for JNJ 16259685 (10)
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Citations are publications that use Bio-Techne products. Selected citations for JNJ 16259685 include:
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Rizwan et al.
(2016)
Long-Term Potentiation at the Mossy Fiber-Granule Cell Relay Invokes Postsynaptic Second-Messenger Regulation of Kv4 Channels.
J Neurosci.
36:11196
PMID: 27807163 -
Tabatadze et al.
(2015)
Sex Differences in Molecular Signaling at Inhibitory Synapses in the Hippocampus.
J Neurosci.
35:11252
PMID: 26269634 -
Johansson et al.
(2015)
Activation of a temporal memory in purkinje cells by the mGluR7 receptor.
Cell Rep..
13:1741
PMID: 26655894 -
Lum et al.
(2014)
mGluR1 within the nucleus accumbens regulates alcohol intake in mice under limited-access conditions.
Neuropharmacology.
79:679
PMID: 24467847 -
Loweth et al.
(2014)
Synaptic depression via mGluR1 positive allosteric modulation suppresses cue-induced cocaine craving.
Nat Neurosci.
17:73
PMID: 24270186 -
Jensen
(2013)
Effects of a metabotropic glutamate 1 receptor antagonist on light responses of retinal ganglion cells in a rat model of retinitis pigmentosa.
PLoS One.
8:e79126
PMID: 24205371 -
Zheng and Raman
(2011)
Prolonged postinhibitory rebound firing in the cerebellar nuclei mediated by group I metabotropic glutamate receptor potentiation of L-type calcium currents.
J Neurosci.
31:10283
PMID: 21753005 -
Hildebrand et al.
(2009)
Functional coupling between mGluR1 and Cav3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines.
J Neurosci.
29:9668
PMID: 19657020 -
Shin et al.
(2008)
Dendritic glutamate release produces autocrine activation of mGluR1 in cerebellar Purkinje cells.
Aquat Toxicol.
105:746
PMID: 18174329 -
Fukunaga et al.
(2007)
Potent and specific action of the mGlu1 antagonists YM-298198 and JNJ16259685 on synaptic transmission in rat cerebellar slices.
Br J Pharmacol.
151:870
PMID: 17502847
There are no citations that match your criteria.