JH-XI-10-02
Tocris Bioscience, part of Bio-Techne | Catalog # 7304
CDK8 Degrader (PROTAC®)
Product Description
JH-XI-10-02 is a CDK8 Degrader (PROTAC®) comprising the cereblon binding ligand Pomalidomide (Cat. No. 6302) joined by a linker to a CDK8 inhibitor. JH-XI-10-02 (1 μM) induces significant proteasome-dependent degradation of CDK8 in Jurkat cells after 24 h, with no significant effect on CDK19 levels.CDK8 antibody validated for Western Blot also available: Catalog # NBP2-92972.
Licensing Information
Sold under license from Dana-Farber Cancer Institute.Product Specifications
Molecular Weight
920.16
Formula
C53H69N5O9
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
15-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-N-[(3β,5α,17β)-17-(7-isoquinolinyl)androstan-3-yl]-N-methyl-4,7,10,13-tetraoxapentadecanamide
CAS Number
2209085-22-1
PubChem ID
145708490
InChI Key
JECHBTRAPARMGI-GFTKVEOVSA-N
SMILES
[H][C@@]12CC[C@@H]([C@]1(CC[C@]3([C@]2(CC[C@]4(C[C@@H](N(C(CCOCCOCCOCCOCCNC5=C6C(N(C(C6=CC=C5)=O)C7CCC(NC7=O)=O)=O)=O)C)CC[C@]34C)[H])[H])[H])C)C8=CC9=C(C=C8)C=CN=C9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.01 | 50 |
Preparing Stock Solutions
for JH-XI-10-02
The following data is based on the product molecular weight 920.16
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 2.17 mL | 10.87 mL | 21.74 mL |
| 2.5 mM | 0.43 mL | 2.17 mL | 4.35 mL |
| 5 mM | 0.22 mL | 1.09 mL | 2.17 mL |
| 25 mM | 0.04 mL | 0.22 mL | 0.43 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hatcher Development of highly potent and selective steroidal inhibitors and degraders of CDK8. ACS Med.Chem.Lett. 2018 PMID: 29937979
Product Specific Notices for JH-XI-10-02
For research use only
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