Potent CCR1 chemokine receptor antagonist
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Key Product Details
Description: | Potent CCR1 chemokine receptor antagonist |
Chemical Name: | 1,4-cis-1-(1-Cycloocten-1-ylmethyl)-4-[[(2,7-dichloro-9H-xanthen-9-yl)carbonyl]amino]-1-ethylpiperidinium iodide |
Purity: | ≥98% (HPLC) |
Molecular Weight: | 655.44 |
Citations for J 113863 (4)
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Citations are publications that use Bio-Techne products. Selected citations for J 113863 include:
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Ansari et al.
(2022)
CCR1 antagonist J-113863 corrects the imbalance of pro- and anti-inflammatory cytokines in a SJL/J mouse model of relapsing-remitting multiple sclerosis.
Immunobiology.
227:152245
PMID: 35868215 -
Kamata et al.
(2015)
The cholesterol-binding protein NPC2 restrains recruitment of stromal macrophage-lineage cells to early-stage lung tumours.
Biomaterials.
7:1119
PMID: 26183450 -
Rowe et al.
(2014)
PGC-1α induces SPP1 to activate macrophages and orchestrate functional angiogenesis in skeletal muscle.
Circ Res.
115:504
PMID: 25009290 -
Gibon et al.
(2012)
Effect of a CCR1 receptor antagonist on systemic trafficking of MSCs and polyethylene particle-associated bone loss.
ScientificWorldJournal.
33:3632
PMID: 22364730
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Customer Reviews for J 113863 (1)
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Species: MouseAssay Type: In VitroCell Line/Tissue: Splenic CellsJ113863 was used in a chemotaxis assay using a subset of C57Bl/6 splenic cells. Cells were pretreated with J113863 for 2 hours before being added to the top portion of a transwell assay. CCL6 or media was used and the chemoattractant and cells were given 2 hours to migrate.As best we can tell, J113863 is entirely insoluble in water containing media. The drug was first dissolved in DMSO, and PBS added to bring to 5% DMSO. As soon as the PBS is added, the drug comes out of solution, however it has proven to still be effective in vitro at concentrations of approximately 1ug/ml and 10ug/ml
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