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J 113863

Tocris Bioscience a Bio-Techne Brand

J 113863 | CAS No. 202796-41-6 | Potent CCR1 chemokine receptor antagonist
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Key Product Details

Description: Potent CCR1 chemokine receptor antagonist
Chemical Name: 1,4-cis-1-(1-Cycloocten-1-ylmethyl)-4-[[(2,7-dichloro-9H-xanthen-9-yl)carbonyl]amino]-1-ethylpiperidinium iodide
Purity: ≥98% (HPLC)
Molecular Weight: 655.44

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  • Effective in blocking mouse CCL6 chemotaxis in vitro
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Splenic Cells
    J113863 was used in a chemotaxis assay using a subset of C57Bl/6 splenic cells. Cells were pretreated with J113863 for 2 hours before being added to the top portion of a transwell assay. CCL6 or media was used and the chemoattractant and cells were given 2 hours to migrate.
    As best we can tell, J113863 is entirely insoluble in water containing media. The drug was first dissolved in DMSO, and PBS added to bring to 5% DMSO. As soon as the PBS is added, the drug comes out of solution, however it has proven to still be effective in vitro at concentrations of approximately 1ug/ml and 10ug/ml
    J 113863 Serum 2595

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