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Ionomycin free acid

Tocris Bioscience a Bio-Techne Brand

Calcium Signaling Agents Small Molecule
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2092/1
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Key Product Details

Description: Calcium ionophore
Chemical Name: (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-10,16-docosadienoic acid
Purity: ≥95% (HPLC)
Molecular Weight: 709.01

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Citations for Ionomycin free acid (1)

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  • Ionomycin releases Ca2+ from intracellular stores.
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: HEK293
    HEK293 cells were loaded with 1 µM intracellular Ca2+ sensitive dye, Fura-2AM in normal tyrode solution for 30 min in dark, washed, and left to equilibrate for 15 min. Fura2-loaded cells were excited alternately at 340 and 380 nm and the fluorescence at 510 nm was expressed as 340/380 ratio to indicate intracellular Ca2+ levels. Application of 1 µM ionomycin in Ca2+-free tyrode solution released Ca2+ from intracellular stores, manifested as a transient peak in fluorescence ratio.
    Ionomycin free acid Serum 2092
  • Ionomycin increases flow of extracellular Ca2+ Into cells leading to increased T-cell activation by IFNg
    Name: Li Zhu
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Primary Cd8+ T-cells
    Ionomycin was used as a calcium ionophore to bring large amounts of extracellular Ca2+ into activated CD8+ T-cells. With high intracellular Ca2+, this led to increased activation of CD8+ T-cells as measured by IFNg production via intracellular flow cytometry.
    Ionomycin free acid Serum 2092

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Product Documents for Ionomycin free acid

Certificate of Analysis

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