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A23187, free acid

Tocris Bioscience a Bio-Techne Brand

A23187, free acid | CAS No. 52665-69-7 | Calcium ionophore
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Key Product Details

Description: Calcium ionophore
Alternative Names: Calcimycin
Chemical Name: 5-(Methylamino)-2-[[2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)-ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid
Purity: ≥98% (HPLC)
Molecular Weight: 523.63

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  • The A23187-induced cytotoxicity cytometrically examined in rat thymocytes
    Name: Lutpine Rachel
    Species: Human
    Assay Type: In Vitro
    A23187 is used to induce Ca(2+)-dependent cell death by increasing intracellular Ca(2+) concentration ([Ca(2+)](i)) under in vitro condition. Since this ionophore also increases membrane permeability of metal divalent cations such as Zn(2+) and Fe(2+) rather than Ca(2+), trace metal cations in cell suspension may affect Ca(2+)-dependent cell death induced by A23187. Therefore, the effects of chelators for divalent metal cations, EDTA and TPEN, on the A23187-induced cytotoxicity were cytometrically examined in rat thymocytes.
    The cytotoxicity of A23187 was attenuated by 1mM EDTA while it was augmented by 50 microM EDTA and 10 microM TPEN.
    A23187, free acid Serum 1234

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Product Documents for A23187, free acid

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