Hesperadin hydrochloride

Product Description

Hesperadin hydrochloride is an ATP-competitive inhibitor of Aurora B kinase (IC₅₀ = 250 nM). Prevents chromosome alignment and segregation; also induces polyploidy and prevents histone H3-Ser10 phosphorylation. Overrides the spindle assembly checkpoint and induces mitotic exit in monastrol- and taxol-treated HeLa cells. Inhibits replication of influenza A and B viral strains (IC₅₀ values range from 0.22 μM to 1.8 μM, dependant on strain), by inhibiting viral RNA transcription and translation

Solubility

Preparing Stock Solutions for Hesperadin hydrochloride

The following data is based on the product molecular weight 553.12

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.81 mL	9.04 mL	18.08 mL
5 mM	0.36 mL	1.81 mL	3.62 mL
10 mM	0.18 mL	0.90 mL	1.81 mL
50 mM	0.04 mL	0.18 mL	0.36 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Hu Chemical genomics approach leads to the identification of hesperadin, an aurora B kinase inhibitor, as a broad-spectrum influenza antiviral. Int.J.Mol.Sci. 2017 PMID: 28885544
• Jetton The cell cycle as a therapeutic target against Trypanosoma brucei: Hesperadin inhibits Aurora kinase-1 and blocks mitotic progression in bloodstream forms. Mol.Microbiol. 2009 PMID: 19320832
• Sessa Mechanism of Aurora B activation by INCENP and inhibition by Hesperadin. Mol.Cell. 2005 PMID: 15866179
• Hauf The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J.Cell.Biol. 2003 PMID: 12707311