Selective inhibitor of mitotic kinesin Eg5
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Key Product Details
Description: | Selective inhibitor of mitotic kinesin Eg5 |
Chemical Name: | 1,2,3,4-Tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-5-pyrimidinecarboxylic acid, ethyl ester |
Purity: | ≥98% (HPLC) |
Molecular Weight: | 292.35 |
Citations for Monastrol (19)
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Citations are publications that use Bio-Techne products. Selected citations for Monastrol include:
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Drpic et al.
(2018)
Chromosome Segregation Is Biased by Kinetochore Size.
Curr Biol.
28:1344
PMID: 29706521 -
Wong et al.
(2018)
Lipid accumulation facilitates mitotic slippage-induced adaptation to anti-mitotic drug treatment.
Cell Death Discov.
4:109
PMID: 30510774 -
Shrestha
(2017)
Aurora-B kinase pathway controls the lateral to end-on conversion of kinetochore-microtubule attachments in human cells.
Nat Commun.
8(1):150
PMID: 28751710 -
Asteriti et al.
(2017)
Identification of small molecule inhibitors of the Aurora-A/TPX2 complex.
Oncotarget.
8:32117
PMID: 28389630 -
Floriot et al.
(2015)
C-Nap1 mutation affects centriole cohesion and is associated with a Seckel-like syndrome in cattle.
Cell Cycle.
6:6894
PMID: 25902731 -
Barr and Bakal
(2015)
A sensitised RNAi screen reveals a ch-TOG genetic interaction network required for spindle assembly.
Nat Commun.
5:10564
PMID: 26037491 -
Asraf et al.
(2015)
Mitotic slippage and expression of survivin are linked to differential sensitivity of human cancer cell-lines to the Kinesin-5 inhibitor monastrol.
PLoS One.
10:e0129255
PMID: 26035434 -
Shrestha and Draviam
(2013)
Lateral to end-on conversion of chromosome-microtubule attachment requires kinesins CENP-E and MCAK.
Curr Biol.
23:1514
PMID: 23891108 -
Corrigan et al.
(2013)
Automated tracking of mitotic spindle pole positions shows that LGN is required for spindle rotation but not orientation maintenance.
Springerplus.
12:2643
PMID: 23907121 -
Habu and Matsumoto
(2013)
p31(comet) inactivates the chemically induced Mad2-dependent spindle assembly checkpoint and leads to resistance to anti-mitotic drugs.
Nature.
2:562
PMID: 24255856 -
Kabeche and Compton
(2013)
Cyclin A regulates kinetochore microtubules to promote faithful chromosome segregation.
J Biol Chem.
502:110
PMID: 24013174 -
Vladimirou et al.
(2013)
Nonautonomous movement of chromosomes in mitosis.
Dev Cell.
27:60
PMID: 24135231 -
Lera and Burkard
(2012)
High mitotic activity of Polo-like kinase 1 is required for chromosome segregation and genomic integrity in human epithelial cells.
J Biol Chem.
287:42812
PMID: 23105120 -
Bartoli et al.
(2011)
Kinesin molecular motor Eg5 functions during polypeptide synthesis.
Mol Biol Cell.
22:3420
PMID: 21795388 -
Bassett et al.
(2010)
Epigenetic centromere specification directs aurora B accumulation but is insufficient to efficiently correct mitotic errors.
Sci Rep.
190:177
PMID: 20643881 -
Samoshkin et al.
(2009)
Human condensin function is essential for centromeric chromatin assembly and proper sister kinetochore orientation.
PLoS One.
4:e6831
PMID: 19714251 -
Vijapurkar et al.
(2007)
Potentiation of kinesin spindle protein inhibitor-induced cell death by modulation of mitochondrial and death receptor apoptotic pathways.
Cancer Res.
67:237
PMID: 17210704 -
Chin
(2006)
Induction of apoptosis by monastrol, an inhibitor of the mitotic kinesin Eg5, is independent of the spindle checkpoint.
Mol Cancer Ther.
5:2580
PMID: 17041103 -
Trinkle-Mulcahy et al.
(2003)
Time-lapse imaging reveals dynamic relocalization of PP1gamma throughout the mammalian cell cycle.
Mol Biol Cell.
14:107
PMID: 12529430
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