Guanylin (human)

Name: Guanylin (human)
Brand: Tocris Bioscience
SKU: 1898

Tocris Bioscience, part of Bio-Techne | Catalog # 1898

COA / SDS

Endogenous activator of intestinal guanylyl cyclase

Key Product Details

Description:	Endogenous activator of intestinal guanylyl cyclase
Purity:	≥95% (HPLC)
Molecular Weight:	1458.65

View Full Technical Details for Guanylin (human)

Technical Data
Citations

Biological Activity for Guanylin (human)

Guanylin (human) is an endogenous peptide activator of intestinal guanylyl cyclase; secreted mainly by the gastrointestinal mucosa. Regulates water and electrolyte transport in intestinal and renal epithelia.

Technical Data for Guanylin (human)

M. Wt	1458.65
Formula	C₅₈H₈₇N₁₅O₂₁S₄
Single Letter Sequence	PGTCEICAYAACTGC (Modifications: Disulfide Bridges: 4-12, 7-15)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	183200-12-6
PubChem ID	90488722
InChi Key	XPNQMTAYRNMRRD-RDJGHUJSSA-N
Smiles	[H]N1CCC[C@H]1C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC3=CC=C(O)C=C3)NC(=O)[C@H](C)NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@@H](NC2=O)[C@@H](C)O)C(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC1=O)[C@@H](C)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Guanylin (human)

Solubility

Soluble to 1mg/ml in water

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References for Guanylin (human)

References are publications that support the biological activity of the product.

Currie Guanylin: an endogenous activator of intestinal guanylate cyclase. Proc.Natl.Acad.Sci.U.S.A. 1992 PMID: 1346555
Nokihara Synthesis, solution structure, binding activity, and cGMP activation of human guanylin and its disulfide isomer. Regul.Pept. 1997 PMID: 9272623
Beltowski Guanylin and related peptides. J.Physiol.Pharmacol. 2001 PMID: 11596856