GSK J5 HCl

Name: GSK J5 HCl
Brand: Tocris Bioscience
SKU: 6935

Tocris Bioscience, part of Bio-Techne | Catalog # 6935

Citations (1)

COA / SDS

Inactive isomer of GSK J4 (Cat. No. 4594); cell permeable

Key Product Details

Description:	Inactive isomer of GSK J4 (Cat. No. 4594); cell permeable
Chemical Name:	N-[2-(3-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	453.97

View Full Technical Details for GSK J5 HCl

Technical Data
Citations

Biological Activity for GSK J5 HCl

GSK J5 HCl is an inactive isomer of GSK J4 (Cat. No. 4594); also cell permeable ester derivative of the inactive control, GSK J2 (Cat. No. 4688).

Active Analog also available.

Licensing Information

This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details of GSK J5, a cell permeable inactive isomer of GSK J1, please visit the GSK J1 probe summary on the SGC website.

Compound Libraries for GSK J5 HCl

GSK J5 HCl is also offered as part of the Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for GSK J5 HCl

M. Wt	453.97
Formula	C₂₄H₂₇N₅O₂.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	1797983-32-4
PubChem ID	126456082
InChi Key	QQHQMHJAOKADED-UHFFFAOYSA-N
Smiles	O=C(CCNC1=NC(C2=CC=CN=C2)=NC(N3CCC(C=CC=C4)=C4CC3)=C1)OCC.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GSK J5 HCl

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	22.7	50

Preparing Stock Solutions for GSK J5 HCl

The following data is based on the product molecular weight 453.97.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.41 mL	22.03 mL	44.06 mL
2.5 mM	0.88 mL	4.41 mL	8.81 mL
5 mM	0.44 mL	2.20 mL	4.41 mL
25 mM	0.09 mL	0.44 mL	0.88 mL

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Reconstitution Calculator

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References for GSK J5 HCl

References are publications that support the biological activity of the product.

Kruidenier A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature 2012 PMID: 22842901