GlyH 101

Name: GlyH 101
Brand: Tocris Bioscience
SKU: 5485

Tocris Bioscience, part of Bio-Techne | Catalog # 5485

Citations (12)

COA / SDS

Reversible, voltage-dependent CFTR chloride channel blocker

Key Product Details

Description:	Reversible, voltage-dependent CFTR chloride channel blocker
Chemical Name:	N-2-Naphthalenyl-2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]glycine hydrazide
Purity:	≥97% (HPLC)
Molecular Weight:	493.15

View Full Technical Details for GlyH 101

Technical Data
Citations

Biological Activity for GlyH 101

GlyH 101 is a reversible, voltage-dependent CFTR chloride channel blocker (K_i = 4.3 μM). Inhibits forskolin-induced hyperpolarization in nasal potential differences and inhibits cholera toxin-induced intestinal fluid secretion in mice.

Technical Data for GlyH 101

M. Wt	493.15
Formula	C₁₉H₁₅Br₂N₃O₃
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	328541-79-3
PubChem ID	11260414
InChi Key	FLGYCSPPJQJZCH-LCYFTJDESA-N
Smiles	O=C(N/N=C/C3=C(O)C(Br)=C(O)C(Br)=C3)CNC2=CC1=CC=CC=C1C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GlyH 101

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	49.31	100

Preparing Stock Solutions for GlyH 101

The following data is based on the product molecular weight 493.15.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.03 mL	10.14 mL	20.28 mL
5 mM	0.41 mL	2.03 mL	4.06 mL
10 mM	0.20 mL	1.01 mL	2.03 mL
50 mM	0.04 mL	0.20 mL	0.41 mL

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Reconstitution Calculator

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References for GlyH 101

References are publications that support the biological activity of the product.

Norimatsu Locating a plausible binding site for an open-channel blocker, GlyH-101, in the pore of the cystic fibrosis transmembrane conductance regulator. Mol.Pharmacol. 2012 PMID: 22923500
Muanprasat Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy. J.Gen.Physiol. 2004 PMID: 15277574