G-36

Name: G-36
Brand: Tocris Bioscience
SKU: 4759

Tocris Bioscience a Bio-Techne Brand

Catalog # 4759

Citations (1)

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Key Product Details

Description:	Selective GPER antagonist
Chemical Name:	(±)-(3aR,4S,9bS*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-8-(1-methylethyl)-3H-cyclopenta[c]quinoline
Purity:	≥99% (HPLC)
Molecular Weight:	412.33

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Biological Activity for G-36

G-36 is an antagonist of GPER; selectively inhibits estrogen-mediated activation of PI3-K by GPER, but not by ERα. Also inhibits estrogen-mediated calcium mobilization (IC₅₀ = 112 nM). Structural analog of G-1 (Cat. No. 3577).

Technical Data for G-36

M. Wt	412.33
Formula	C₂₂H₂₂BrNO₂
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	1392487-51-2
PubChem ID	73755224
InChi Key	QTOCPACSSHFGOY-ZCCHDVMBSA-N
Smiles	BrC1=CC4=C(OCO4)C=[C@@]1[C@@H]2NC(C=CC(C(C)C)=C5)=C5[C@@]3([H])[C@@]([H])2CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for G-36

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	41.23	100

Preparing Stock Solutions for G-36

The following data is based on the product molecular weight 412.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.43 mL	12.13 mL	24.25 mL
5 mM	0.49 mL	2.43 mL	4.85 mL
10 mM	0.24 mL	1.21 mL	2.43 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

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References for G-36

References are publications that support the biological activity of the product.

Prossnitz and Barton The G-protein-coupled estrogen receptor GPER in health and disease. Nat.Rev.Endocrinol. 2011 PMID: 21844907
Dennis Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity. J.Steroid Biochem.Mol.Biol. 2011 PMID: 21782022

Citations for G-36 (1)

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Citations are publications that use Bio-Techne products. Selected citations for G-36 include:

Meseke et al. (2018) Distal Dendritic Enrichment of HCN1 Channels in Hippocampal CA1 Is Promoted by Estrogen, but Does Not Require Reelin. Eneuro. 5
PMID: 30406178

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Product Documents for G-36

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.