FSEN 1
Tocris Bioscience, part of Bio-Techne | Catalog # 7941
Induces ferroptosis; inhibits FSP1
Key Product Details
Description
Induces ferroptosis; inhibits FSP1
Product Description
FSEN 1 is a ferroptosis suppressor protein 1 (FSP1) inhibitor (IC50 = 313 nM). FSEN 1 sensitizes lung cancer cells and organoids to ferroptosis (EC50 = 69 nM) through inhibition of FSP1. Inhibits FSP1 CoQ1 oxidoreductase activity (IC50 = 688 nM).Product Specifications
Molecular Weight
484.42
Formula
C22H22BrN5OS
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
3-(4-Bromophenyl)-6-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)thiazolo[2,3-c][1,2,4]triazole
CAS Number
862808-01-3
PubChem ID
22583648
InChI Key
JGXIXBKKDUNARN-UHFFFAOYSA-N
SMILES
BrC1=CC=C(C2=NN=C3SC(CN4CCN(CC4)C5=CC=C(C=C5)OC)=CN32)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.69 | 20 |
Preparing Stock Solutions
for FSEN 1
The following data is based on the product molecular weight 484.42
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 10.32 mL | 51.61 mL | 103.22 mL |
| 1 mM | 2.06 mL | 10.32 mL | 20.64 mL |
| 2 mM | 1.03 mL | 5.16 mL | 10.32 mL |
| 10 mM | 0.21 mL | 1.03 mL | 2.06 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hendricks Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis. Cell Chem.Biol. 2023 PMID: 37178691
Product Specific Notices for FSEN 1
For research use only
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