FPL 64176

Name: FPL 64176
Brand: Tocris Bioscience
SKU: 1403

Tocris Bioscience, part of Bio-Techne | Catalog # 1403

Citations (46)

COA / SDS

Potent CaV1.x activator

Key Product Details

Description:	Potent Ca_V1.x activator
Chemical Name:	2,5-Dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylic acid methyl ester
Purity:	≥97% (HPLC)
Molecular Weight:	347.41

View Full Technical Details for FPL 64176

Technical Data
Citations

Biological Activity for FPL 64176

FPL 64176 is a potent activator of L-type Ca²⁺ channels (EC₅₀ = 16 nM). 40-fold more potent than Bay K 8644 (Cat. No. 1544) as a positive inotrope in guinea pig atria.

Technical Data for FPL 64176

M. Wt	347.41
Formula	C₂₂H₂₁NO₃
Storage	Store at RT
Purity	≥97% (HPLC)
CAS Number	120934-96-5
PubChem ID	3423
InChi Key	MDMWHKZANMNXTF-UHFFFAOYSA-N
Smiles	COC(=O)C1=C(C)NC(C)=C1C(=O)C1=CC=CC=C1CC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for FPL 64176

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	8.69	25
	DMSO	17.37	50

Preparing Stock Solutions for FPL 64176

The following data is based on the product molecular weight 347.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.76 mL	28.78 mL	57.57 mL
2.5 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.58 mL	2.88 mL	5.76 mL
25 mM	0.12 mL	0.58 mL	1.15 mL

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Reconstitution Calculator

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References for FPL 64176

References are publications that support the biological activity of the product.

Rampe Comparison of the in vitro and in vivo cardiovascular effects of two structurally distinct Ca⁺⁺ channel activators, BAY K 8644 and FPL 64176. J.Pharmacol.Exp.Ther. 1993 PMID: 7685384
Zheng Pharmacological, radioligand binding, and electrophysiological characteristics of FPL 64176, a novel nondihydropyridine Ca²⁺ channel activator, in cardiac and vascular preparations. Mol.Pharmacol. 1991 PMID: 1719369
Baxter Discovery and synthesis of methyl 2,5-dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylate (FPL 64176) and analogues: the first examples of a new class of calcium channel activator. J.Med.Chem. 1993 PMID: 7692047