Ferrostatin 1

Product Description

Ferrostatin 1 is a selective inhibitor of erastin induced ferroptosis (EC₅₀ = 60 nM). Specifically inhibits Ras selective lethal compound -induced death, but not cell death induced by other oxidative lethal compounds and apoptosis-inducing agents. Inhibits ferroptosis in cancer cells; also inhibits glutamate-induced cell death in organotypic rat brain slices. Prevents erastin induced accumulation of cytosolic and lipid reactive oxygen species.

Solubility

Preparing Stock Solutions for Ferrostatin 1

The following data is based on the product molecular weight 262.35

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.81 mL	19.06 mL	38.12 mL
5 mM	0.76 mL	3.81 mL	7.62 mL
10 mM	0.38 mL	1.91 mL	3.81 mL
50 mM	0.08 mL	0.38 mL	0.76 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Louandre Iron-dependent cell death of hepatocellular carcinoma cells exposed to sora. Int.J.Cancer 2013 PMID: 23505071
• Skouta FerroSTAT inhibit oxidative lipid damage and cell death in diverse disease models. J.Am.Chem.Soc. 2014 PMID: 24592866
• Dixon Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 2012 PMID: 22632970