endo-IWR 1

Tocris Bioscience, part of Bio-Techne | Catalog # 3532

Wnt/β-catenin signaling inhibitor; axin stabilizer
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Key Product Details

Description

Wnt/β-catenin signaling inhibitor; axin stabilizer

View all beta-Catenin Compounds »

Product Description

endo-IWR 1 is an inhibitor of Wnt signaling. Induces an increase in axin2 protein levels; promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes. Promotes endothelial cell specification of cardiac progenitor cells and may be used in protocols for the generation of retinal pigment epithelial cells from hPSCs, and for the generation and propagation of EPS cells (see our protocol below).

Negative Control also available.

endo-IWR 1 synthesized to Ancillary Material Grade also available.

For more information about how endo-IWR 1 may be used, see our protocol: Generation and Propagation of EPS cells (LCDM Cocktail).

Product Specifications

Molecular Weight

409.44

Formula

C25H19N3O3

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide

CAS Number

1127442-82-3

PubChem ID

90488854

InChI Key

ZGSXEXBYLJIOGF-ALFLXDJESA-N

SMILES

[H][C@]13[C@](C(N(C4=CC=C(C(NC5=CC=CC6=C5N=CC=C6)=O)C=C4)C3=O)=O)([H])[C@H]2C=C[C@@H]1C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.94 100

Preparing Stock Solutions for endo-IWR 1

The following data is based on the product molecular weight 409.44

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.44 mL 12.21 mL 24.42 mL
5 mM 0.49 mL 2.44 mL 4.88 mL
10 mM 0.24 mL 1.22 mL 2.44 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

Calculators

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Product Documents for endo-IWR 1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for endo-IWR 1

For research use only

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