exo-IWR 1
Tocris Bioscience, part of Bio-Techne | Catalog # 3947
Negative control for endo-IWR 1 (Cat. No. 3532)
Discontinued Product
3947 has been discontinued.
View all beta-Catenin Compounds products.
Key Product Details
Description
Negative control for endo-IWR 1 (Cat. No. 3532)
Product Description
exo-IWR 1 is a negative control for endo-IWR 1 25-fold less active than endo-IWR 1; exhibits decreased activity against the Wnt/β-catenin pathway.Active Analog also available.
Product Specifications
Molecular Weight
409.44
Formula
C25H19N3O3
Storage
Store at RT
Purity
≥99% (HPLC)
Chemical Name
4-[(3aR,4R,7S,7aS-rel)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide
CAS Number
1127442-87-8
PubChem ID
1163034
InChI Key
ZGSXEXBYLJIOGF-BTYSMDAFSA-N
SMILES
O=C(NC5=CC=CC6=C5N=CC=C6)C(C=C4)=CC=C4N2C([C@@]1([H])[C@@H](C3)C=C[C@@H]3[C@]([H])1C2=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.94 | 100 |
Preparing Stock Solutions
for exo-IWR 1
The following data is based on the product molecular weight 409.44
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.44 mL | 12.21 mL | 24.42 mL |
| 5 mM | 0.49 mL | 2.44 mL | 4.88 mL |
| 10 mM | 0.24 mL | 1.22 mL | 2.44 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.49 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Chen Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nature Chem.Biol.
- Lu Structure-activity relationship studies of small-molecule inhibitors of Wnt response. Bioorg.Med.Chem.Lett. 2009 PMID: 19410457
Product Specific Notices for exo-IWR 1
For research use only
Loading...
Loading...