Emetine dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 7342

RNA polymerase inhibitor; inhibits replication of a broad range of RNA and DNA viruses, including SARS-CoV-2 and Zika
Catalog #
Availability
Size / Price
Qty
7342/50
Print Quote
Bulk Order
100% Guarantee

Key Product Details

Description

RNA polymerase inhibitor; inhibits replication of a broad range of RNA and DNA viruses, including SARS-CoV-2 and Zika

View all RNA/DNA Polymerase Inhibitors »

Product Description

Emetine is a RNA polymerase inhibitor. It inhibits SARS-CoV-2 replication (EC50 = 460 nM) and in combination with Remdesivir (Cat. No.7226) synergistically inhibits the viral yield of SARS-CoV-2 by 64.9%. Emetine attenuates hCoV-OC43, hCoV-NL43, SARS-CoV, MERS-CoV, and MHV-A59 in vitro with EC50 values in the low micromolar range. It also inhibits replication of a broad range of RNA and DNA viruses, including influenza, ebolavirus and HIV-1. Emetine potently inhibits ZIKV replication in vitro (IC50 = 52.9 nm) and suppresses ZIKV viral load in vivo. Anti-inflammatory, antiviral, antimalarial, antibacterial and anti-amebic.

Product Specifications

Molecular Weight

553.57

Formula

C29H40N2O4.2HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(2S,3R,11bS)-3-Ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolinyl]methyl]-2H-benzo[a]quinolizine dihydrochloride

CAS Number

316-42-7

PubChem ID

3068143

InChI Key

JROGBPMEKVAPEH-GXGBFOEMSA-N

SMILES

[H][C@@]1(NCCC2=CC(OC)=C(C=C12)OC)C[C@H]3C[C@@]4(N(C[C@@H]3CC)CCC5=CC(OC)=C(C=C45)OC)[H].Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 55.36 100

Preparing Stock Solutions for Emetine dihydrochloride

The following data is based on the product molecular weight 553.57

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.81 mL 9.03 mL 18.06 mL
5 mM 0.36 mL 1.81 mL 3.61 mL
10 mM 0.18 mL 0.90 mL 1.81 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

x
=
x

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product.

Product Documents for Emetine dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Emetine dihydrochloride

For research use only

Privacy Policy
Cookie Policy
Site Map
© Copyright 2026 Bio-Techne. All Rights Reserved. All trademarks and registered trademarks are the property of Bio-Techne and its brands unless otherwise specified.