Remdesivir

Name: Remdesivir
Brand: tocris
SKU: 7226

Catalog # 7226

Datasheet / COA / SDS

Order Information

For ordering and shipping information please contact your local Bio-Techne office or distributor.

Key Product Details

Description:	Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral nucelotide prodrug
Alternative Names:	GS-5734
Chemical Name:	2-Ethylbutyl (2S)-2-[[(S)-[[(2R,3S,4R,5R)-5-(4-aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy]phenoxyphosphoryl]amino]propanoate
Purity:	≥98% (HPLC)
Molecular Weight:	602.58

View Full Technical Details for Remdesivir

Biological Activity

Remdesivir is a viral RNA-dependent RNA polymerase inhibitor (RdRp) and broad spectrum antiviral nucleotide prodrug. Metabolized to active form, GS 441524 (Cat. No. 7227). Exhibits activity against a range of RNA viruses in vitro (EC₅₀ values are 0.019, 0.07, 0.07 - 0.34, 0.086 - 0.14, and 23.15 μM against RSV, SARS-CoV, MERS-CoV, EBOV and SARS-CoV-2, respectively). Exhibits antiviral efficacy in animal models of MERS-CoV and EBOV infection.

Compound Libraries

Remdesivir is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	602.58
Formula	C₂₇H₃₅N₆O₈P
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1809249-37-3
PubChem ID	121304016
InChi Key	RWWYLEGWBNMMLJ-YSOARWBDSA-N
Smiles	CCC(COC([C@@H](N[P@](OC[C@H]1O[C@]([C@@H]([C@@H]1O)O)(C2=CC=C3N2N=CN=C3N)C#N)(OC4=CC=CC=C4)=O)C)=O)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	60.26	100
	ethanol	12.05	20

Preparing Stock Solutions

The following data is based on the product molecular weight 602.58.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.66 mL	8.30 mL	16.60 mL
5 mM	0.33 mL	1.66 mL	3.32 mL
10 mM	0.17 mL	0.83 mL	1.66 mL
50 mM	0.03 mL	0.17 mL	0.33 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References

References are publications that support the biological activity of the product.

Sheahan Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV. Nat.Commun. 2020 PMID: 31924756
Warren Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys. Nature 2016 PMID: 26934220
Choy Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2replication in vitro. Antiviral Res. 2020 PMID: 32251767