Edelfosine

Name: Edelfosine
Brand: Tocris Bioscience
SKU: 3022
Rating: 4 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 3022

Citations (9)

(1)

COA / SDS

New Version Available - 7462

Discontinued Product

3022 has been discontinued and is replaced by 7462.

Key Product Details

Description:	Selective PI-PLC inhibitor, also PAF receptor agonist
Alternative Names:	ET-18-OCH₃
Chemical Name:	(7R)-4-Hydroxy-7-methoxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphaheptacosan-1-aminium-4-oxide
Molecular Weight:	523.73

View Full Technical Details for Edelfosine

Biological Activity for Edelfosine

Edelfosine is a synthetic lysophospholipid analog that selectively inhibits phosphatidylinositol phospholipase C (IC₅₀= 9.6 μM in fibroblasts and adenocarcinoma cells). Also acts as an agonist at platelet-activating factor (PAF) receptors. Antitumor lipid; selectively induces apoptosis in tumor cells, sparing normal cells.

Technical Data for Edelfosine

M. Wt	523.73
Formula	C₂₇H₅₈NO₆P
Storage	Store at -20°C
CAS Number	77286-66-9
PubChem ID	6918215
InChi Key	MHFRGQHAERHWKZ-HHHXNRCGSA-N
Smiles	CO[C@@H](COP(OCC[N+](C)(C)C)([O-])=O)COCCCCCCCCCCCCCCCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Edelfosine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	2.62	5 with gentle warming

Preparing Stock Solutions for Edelfosine

The following data is based on the product molecular weight 523.73.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	38.19 mL	190.94 mL	381.88 mL
0.25 mM	7.64 mL	38.19 mL	76.38 mL
0.5 mM	3.82 mL	19.09 mL	38.19 mL
2.5 mM	0.76 mL	3.82 mL	7.64 mL

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Reconstitution Calculator

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References for Edelfosine

References are publications that support the biological activity of the product.

Shimizu Roles of brain phosphatidylinositol-specific phospholipase C and diacylglycerol lipase in centrally administered histamine-induced adrenomedullary outflow in rats. Eur.J.Pharmacol. 2007 PMID: 17628524
Wong Phospholipase C and myosin light chain kinase inhibition define a common step in actin regulation during cytokinesis. BMC Cell Biol. 2007 PMID: 17509155
Aoki A radioreceptor binding assay for platelet-activating factor (PAF) using membranes from CHO cells expressing human PAF receptor. J.Immunol.Methods 1995 PMID: 7594622
Powis Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues. Cancer Res. 1992 PMID: 1316230

Citations for Edelfosine (9)

Showing 1 - 9 of 9 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Edelfosine include:

Pitt et al. (2017) Neuroprotective astrocyte-derived Ins/IGF-1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers. Mol Biol Cell. 28:2623
PMID: 28963439
Yu et al. (2017) PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development. Nat Commun. 8:1457
PMID: 29133930
Ailte et al. (2017) Exogenous lysophospholipids with large head groups perturb clathrin-mediated endocytosis. Traffic. 18:176
PMID: 28067430
Liu et al. (2015) A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis. Sci Signal. 8:ra71
PMID: 26198357
Ozkucur et al. (2014) NHE3 phosphorylation via PKCη marks the polarity and orientation of directionally migrating cells. Cell Mol Life Sci. 71:4653
PMID: 24788043
Zhao (2014) BDNF-endocannabinoid interactions at neocortical inhibitory synapses require phospholipase C signaling. J Neurophysiol. 111:1008
PMID: 24335212
Korb et al. (2013) Arc in the nucleus regulates PML-dependent GluA1 transcription and homeostatic plasticity. Nat Neurosci. 16:874
PMID: 23749147
Lee et al. (2012) The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca²⁺ and cAMP. Nature. 492:123
PMID: 23143333
Melchior and Frangos (2012) Gαq/11-mediated intracellular calcium responses to retrograde flow in endothelial cells. Cancer Biol Ther. 303:C467
PMID: 22700794

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Customer Reviews for Edelfosine (1)

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works well

Name: Anonymous

Species: Rat

Assay Type: In Vitro

Cell Line/Tissue: Hippocampal neuron

10uM

PMID: PMID: 28963439

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