ET 18-OCH3
Tocris Bioscience, part of Bio-Techne | Catalog # 7462
Selective PI-PLC inhibitor, also PAF receptor agonist
Key Product Details
Description
Selective PI-PLC inhibitor, also PAF receptor agonist
Product Description
ET 18-OCH3 is a synthetic lysophospholipid analog that selectively inhibits phosphatidylinositol phospholipase C (IC50 = 9.6 μM in fibroblasts and adenocarcinoma cells). ET 18-OCH3 acts as an agonist at platelet-activating factor (PAF) receptors. ET 18-OCH3 is an antitumor lipid that selectively induces apoptosis in tumor cells, sparing normal cells, and activates the intracellular Fas/CD95 death receptor. ETH 18-OCH3 also triggers eryptosis and interacts with mitochondrial membranes to increase mitochondrial membrane permeability, leading to dysfunction and apoptosis. Racemic mixture.Product Specifications
Molecular Weight
523.73
Formula
C27H58NO6P
Storage
Store at -20°C
Chemical Name
4-Hydroxy-7-methoxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphaheptacosan-1-aminium 4-oxide
CAS Number
70641-51-9
PubChem ID
1392
InChI Key
MHFRGQHAERHWKZ-UHFFFAOYSA-N
SMILES
COC(COP(OCC[N+](C)(C)C)([O-])=O)COCCCCCCCCCCCCCCCCCC
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 10.47 | 20 |
Preparing Stock Solutions
for ET 18-OCH3
The following data is based on the product molecular weight 523.73
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 9.55 mL | 47.73 mL | 95.47 mL |
| 1 mM | 1.91 mL | 9.55 mL | 19.09 mL |
| 2 mM | 0.95 mL | 4.77 mL | 9.55 mL |
| 10 mM | 0.19 mL | 0.95 mL | 1.91 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wong Phospholipase C and myosin light chain kinase inhibition define a common step in actin regulation during cytokinesis. BMC Cell Biol. 2007 PMID: 17509155
- Shimizu Roles of brain phosphatidylinositol-specific phospholipase C and diacylglycerol lipase in centrally administered histamine-induced adrenomedullary outflow in rats. Eur.J.Pharmacol. 2007 PMID: 17628524
- Aoki A radioreceptor binding assay for platelet-activating factor (PAF) using membranes from CHO cells expressing human PAF receptor. J.Immunol.Methods 1995 PMID: 7594622
- Powis Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues. Cancer Res. 1992 PMID: 1316230
- Briglia Edelfosine induced suicidal death of human erythrocytes. Cell.Physiol.Biochem. 2015 PMID: 26618532
- Mollinedo ET-18-OCH3 (edelfosine): a selective antitumour lipid targeting apoptosis through intracellular activation of Fas/CD95 death receptor. Curr.Med.Chem. 2004 PMID: 15579006
Product Specific Notices for ET 18-OCH3
For research use only
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