Ebselen

Product Description

Ebselen is a glutathione peroxidase mimic; peroxynitrite scavenger. Inhibits ferroptosis. Also inhibits lipoxygenase, cyclooxygenase, nitric oxide synthase, protein kinase C and H⁺/K⁺-ATPase activity. Inhibits the hepatic carcinogenic effects of aflatoxin B₁. Antioxidant and anti-inflammatory. Selectively inhibits G_q protein signaling and enhances differentiation of brown adipocytes. Inhibits SARS-CoV-2 M^pro in vitro (IC₅₀ = 0.67 μM in FRET assay)

Solubility

Preparing Stock Solutions for Ebselen

The following data is based on the product molecular weight 274.18

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.65 mL	18.24 mL	36.47 mL
5 mM	0.73 mL	3.65 mL	7.29 mL
10 mM	0.36 mL	1.82 mL	3.65 mL
50 mM	0.07 mL	0.36 mL	0.73 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Jin Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors. Nature. 2020 PMID: 32272481
• Xie Ferroptosis: process and function. Cell Death Differ. 2016 PMID: 26794443
• Kuschak Cell-permeable high-affinity tracers for G_q proteins provide structural insights, reveal distinct binding kinetics, and identify small molecule inhibitors. Br.J.Pharmacol. 2019 PMID: 31881095
• Fujisawa and Kadoma Kinetic studies of the radical-scavenging activity of ebselen, a seleno-organic compound. Anticancer Res. 2005 PMID: 16309189
• Yang Inhibition of ebselen on aflatoxin B(1)-induced hepatocarcinogenesis in Fischer 344 rats. Carcinogenesis 2000 PMID: 11133813
• Schewe Molecular actions of ebselen--an antiinflammatory antioxidant. Gen.Pharmacol. 1995 PMID: 7590103