DPCPX
Tocris Bioscience, part of Bio-Techne | Catalog # 0439
Selective A1 antagonist
Key Product Details
Description
Selective A1 antagonist
Product Description
DPCPX is a potent and selective A1 adenosine receptor antagonist, both in vitro and in vivo. Ki values are 3.9, 130, 50 and 4000 nM for human A1, A2A, A2B and A3 receptors respectively.Product Specifications
Molecular Weight
304.39
Formula
C16H24N4O2
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
8-Cyclopentyl-1,3-dipropylxanthine
CAS Number
102146-07-6
PubChem ID
1329
InChI Key
FFBDFADSZUINTG-UHFFFAOYSA-N
SMILES
CCCN1C2=C(N=C(N2)C2CCCC2)C(=O)N(CCC)C1=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 1.52 | 5 with gentle warming | |
| Ethanol | 3.04 | 10 with gentle warming |
Preparing Stock Solutions
for DPCPX
The following data is based on the product molecular weight 304.39
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 32.85 mL | 164.26 mL | 328.53 mL |
| 0.5 mM | 6.57 mL | 32.85 mL | 65.71 mL |
| 1 mM | 3.29 mL | 16.43 mL | 32.85 mL |
| 5 mM | 0.66 mL | 3.29 mL | 6.57 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Von der Leyen Effects of 1,3-dipropyl-8-cyclopentylxanthine (DPCPX), a highly selective adenosine receptor antagonist, on force of contraction in guinea-pig atrial and ventricular cardiac preparations. Naunyn Schmiedebergs Arch.Pharmacol. 1989 PMID: 2554151
- Klotz Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch.Pharmacol. 2000 PMID: 11111832
- Kuan An experimental paradigm for investigating the role of endogenous adenosine/A1 receptor interactions in vivo. J.Pharmacol.Exp.Ther. 1992 PMID: 1432696
- Canals Metabolic challenge to glia activates and adenosine-mediated safety mechanism that promotes neuronal survival by delaying the onset of spreading depression waves. J.Cereb.Blood Flow Metab. 2008 PMID: 18612316
Product Specific Notices for DPCPX
For research use only
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