DNQX

Citations are publications that use Bio-Techne products. Selected citations for DNQX include:

• Flossmann et al. (2019) Somatostatin Interneurons Promote Neuronal Synchrony in the Neonatal Hippocampus. Cell Rep. 26:3173
  PMID: 30893591
• Meijer et al. (2019) A Single-Cell Model for Synaptic Transmission and Plasticity in Human iPSC-Derived Neurons. Cell Rep. 27:2199
  PMID: 31091456
• Cai and Ford (2018) DA Cells Differentially Regulate Striatal Cholinergic Transmission across Regions through Corelease of DA and Glutamate. Cell Rep. 25:3148
  PMID: 30540946
• González-Rueda et al. (2018) Activity-Dependent Downscaling of Subthreshold Synaptic Inputs during Slow-Wave-Sleep-like Activity In Vivo. Neuron. 97:1244
  PMID: 29503184
• Thalman et al. (2018) Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders. Mol Psychiatry. 23(8):1699
  PMID: 29743582
• Ferlauto et al. (2018) Design and validation of a foldable and photovoltaic wide-field epiretinal prosthesis. Nat Commun. 9:992
  PMID: 29520006
• Ahsan Raza (2017) HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience. Nat Commun. 8(1):189
  PMID: 28775269
• Thomsen et al. (2016) Fixed single-cell transcriptomic characterization of human radial glial diversity. Nat Methods. 13:87
  PMID: 26524239
• Fan et al. (2016) Reduced Hyperpolarization-Activated Current Contributes to Enhanced Intrinsic Excitability in Cultured Hippocampal Neurons from PrP(-/-) Mice. Front Cell Neurosci. 10:74
  PMID: 27047338
• Zhang et al. (2016) Loss of MeCP2 in cholinergic neurons causes part of RTT-like phenotypes via α7 receptor in hippocampus. Cell Res. 26:728
  PMID: 27103432
• Choe et al. (2015) High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons. Neuron. 85:549
  PMID: 25619659
• Arama et al. (2015) GABAA receptor activity shapes the formation of inhibitory synapses between developing medium spiny neurons. Front Cell Neurosci. 9:290
  PMID: 26300728
• Deidda et al. (2015) Early depolarizing GABA controls critical-period plasticity in the rat visual cortex. Nat Neurosci. 18:87
  PMID: 25485756
• Rosa et al. (2015) Neuron-glia signaling in developing retina mediated by neurotransmitter spillover. Elife. 4
  PMID: 26274565
• Reifler et al. (2015) The rat retina has five types of ganglion-cell photoreceptors. Exp Eye Res. 130:17
  PMID: 25450063
• Konopacka et al. (2015) Osmoregulation requires brain expression of the renal Na-K-2Cl cotransporter NKCC2. J Neurosci. 35:5144
  PMID: 25834041
• Sexton et al. (2015) Type I intrinsically photosensitive retinal ganglion cells of early post-natal development correspond to the M4 subtype. Neural Dev. 10:17
  PMID: 26091805
• Haj-Yasein et al. (2015) Deletion of aquaporin-4 increases extracellular K(+) concentration during synaptic stimulation in mouse hippocampus. Brain Struct Funct. 220:2469
  PMID: 24744149
• Cramer et al. (2015) Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse. J Neurosci. 35:5664
  PMID: 25855180
• Vance et al. (2015) PAR1-activated astrocytes in the nucleus of the solitary tract stimulate adjacent neurons via NMDA receptors. J Neurosci. 35:776
  PMID: 25589770
• Hososhima et al. (2015) Kinetic evaluation of photosensitivity in bi-stable variants of chimeric channelrhodopsins. PLoS One. 10:e0119558
  PMID: 25789474
• Morrie and Feller (2015) An Asymmetric Increase in Inhibitory Synapse Number Underlies the Development of a Direction Selective Circuit in the Retina. J Neurosci. 35:9281
  PMID: 26109653
• Owen and Grover (2015) Activity-dependent differences in function between proximal and distal Schaffer collaterals. J Neurophysiol. 113:3646
  PMID: 25855695
• Bajo et al. (2015) IL-1 interacts with ethanol effects on GABAergic transmission in the mouse central amygdala. Front Pharmacol. 6:49
  PMID: 25852553
• Liu et al. (2015) Morphological and physiological evidence of a synaptic connection between the lateral parabrachial nucleus and neurons in the A7 catecholamine cell group in rats. J Biomed Sci. 22:79
  PMID: 26385355
• Malyshev et al. (2015) Advantages and limitations of the use of optogenetic approach in studying fast-scale spike encoding. PLoS One. 10:e0122286
  PMID: 25850004
• Dorris et al. (2015) Intrinsic excitability varies by sex in prepubertal striatal medium spiny neurons. J Neurophysiol. 113:720
  PMID: 25376786
• Zhao (2014) BDNF-endocannabinoid interactions at neocortical inhibitory synapses require phospholipase C signaling. J Neurophysiol. 111:1008
  PMID: 24335212
• Lee et al. (2014) Synapse elimination and learning rules co-regulated by MHC class I H2-Db. Nature. 509:195
  PMID: 24695230
• Jones et al. (2014) Neonatal NMDA receptor blockade disrupts spike timing and glutamatergic synapses in fast spiking interneurons in a NMDA receptor hypofunction model of schizophrenia. PLoS One. 9:e109303
  PMID: 25290690
• Kallupi et al. (2014) Nociceptin/orphanin FQ decreases glutamate transmission and blocks ethanol-induced effects in the central amygdala of naive and ethanol-dependent rats. Neuropsychopharmacology. 39:1081
  PMID: 24169802
• Pedroni et al. (2014) Electrophysiological characterization of granule cells in the dentate gyrus immediately after birth. Front Cell Neurosci. 8:44
  PMID: 24592213
• Dragicevic et al. (2014) Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra DA neurons. Brain. 137:2287
  PMID: 24934288
• Castaño et al. (2014) Fast and efficient neural conversion of human hematopoietic cells. Stem Cell Reports. 3:1118
  PMID: 25458894
• Llano et al. (2014) An auditory colliculothalamocortical brain slice preparation in mouse. J Neurophysiol. 111:197
  PMID: 24108796
• Cijsouw et al. (2014) Munc18-1 redistributes in nerve terminals in an activity- and PKC-dependent manner. J Cell Biol. 204:759
  PMID: 24590174
• Armbruster et al. (2014) Laser-scanning astrocyte mapping reveals increased glutamate-responsive domain size and disrupted maturation of glutamate uptake following neonatal cortical freeze-lesion. Front Cell Neurosci. 8:277
  PMID: 25249939
• Dale et al. (2014) Vort. disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus. J Psychopharmacol. 28:891
  PMID: 25122043
• Albrecht et al. (2014) Inhibitory projections from the ventral nucleus of the trapezoid body to the medial nucleus of the trapezoid body in the mouse. Front Neural Circuits. 8:83
  PMID: 25120436
• Armbrust et al. (2014) Mutant β-III spectrin causes mGluR1α mislocalization and functional deficits in a mouse model of spinocerebellar ataxia type 5. J Neurosci. 34:9891
  PMID: 25057192
• Rovó et al. (2014) Phasic, nonsynaptic GABA-A receptor-mediated inhibition entrains thalamocortical oscillations. J Neurosci. 34:7137
  PMID: 24849349
• Deeb et al. (2013) Disrupted Cl(-) homeostasis contributes to reductions in the inhibitory efficacy of D.pam during hyperexcited states. Eur J Neurosci. 38:2453
  PMID: 23627375
• Fuchs et al. (2013) GABA(A) receptors can initiate the formation of functional inhibitory GABAergic synapses. Eur J Neurosci. 38:3146
  PMID: 23909897
• Boehlen et al. (2013) Contribution of near-threshold currents to intrinsic oscillatory activity in rat medial entorhinal cortex layer II stellate cells. J Neurophysiol. 109:445
  PMID: 23076110
• Lau et al. (2013) A conformational intermediate in glutamate receptor activation. Neuron. 79:492
  PMID: 23931998
• Cruz et al. (2013) Ghrelin increases GABAergic transmission and interacts with ethanol actions in the rat central nucleus of the amygdala. Neuropsychopharmacology. 38:364
  PMID: 22968812
• Caiati et al. (2013) PrPC controls via protein kinase A the direction of synaptic plasticity in the immature hippocampus. J Neurosci. 33:2973
  PMID: 23407955
• Crawford et al. (2013) Social stress alters inhibitory synaptic input to distinct subpopulations of raphe serotonin neurons. ACS Chem Neurosci. 4:200
  PMID: 23336059
• Cusulin et al. (2013) Characterization of corticotropin-releasing hormone neurons in the paraventricular nucleus of the hypothalamus of Crh-IRES-Cre mutant mice. PLoS One. 8:e64943
  PMID: 23724107
• Rehak et al. (2013) Low voltage activation of KCa1.1 current by Cav3-KCa1.1 complexes. PLoS One. 8:e61844
  PMID: 23626738
• Pasquale and Sherman (2013) A modulatory effect of the feedback from higher visual areas to V1 in the mouse. J Neurophysiol. 109:2618
  PMID: 23446698
• Lee et al. (2013) TRPM2 channels are required for NMDA-induced burst firing and contribute to H(2)O(2)-dependent modulation in substantia nigra pars reticulata GABAergic neurons. J Neurosci. 33:1157
  PMID: 23325252
• Bengtson et al. (2013) Calcium responses to synaptically activated bursts of action potentials and their synapse-independent replay in cultured networks of hippocampal neurons. Biochim Biophys Acta. 1833:1672
  PMID: 23360982
• Bajo et al. (2012) Receptor subtype-dependent galanin actions on gamma-aminobutyric acidergic neurotransmission and ethanol responses in the central amygdala. Addict Biol. 17:694
  PMID: 21955024
• Grant et al. (2012) Development of the corticothalamic projections. Front Neurosci. 6:53
  PMID: 22586359
• Hook et al. (2012) DArgic modulation of ganglion-cell photoreceptors in rat. Eur J Neurosci. 35:507
  PMID: 22304466
• Hnasko et al. (2012) Ventral tegmental area glutamate neurons: electrophysiological properties and projections. J Neurosci. 32:15076
  PMID: 23100428
• Saliba et al. (2012) Activity-dependent phosphorylation of GABAA receptors regulates receptor insertion and tonic current. EMBO J. 31:2937
  PMID: 22531784
• Haam et al. (2012) GABA is excitatory in adult vasopressinergic neuroendocrine cells. J Neurosci. 32:572
  PMID: 22238092
• Bospoort et al. (2012) Munc13 controls the location and efficiency of dense-core vesicle release in neurons. J Cell Biol. 199:883
  PMID: 23229896
• Messer and Levine (2012) Epileptiform activity in the CA1 region of the hippocampus becomes refractory to attenuation by cannabinoids in part because of endogenous γ-aminobutyric acid type B receptor activity. J Neurosci Res. 90:1454
  PMID: 22388975
• Engbers et al. (2012) Intermediate conductance calcium-activated potassium channels modulate summation of parallel fiber input in cerebellar Purkinje cells. Proc Natl Acad Sci U S A. 109:2601
  PMID: 22308379
• Laviv et al. (2011) Compartmentalization of the GABAB receptor signaling complex is required for presynaptic inhibition at hippocampal synapses. J Neurosci. 31:12523
  PMID: 21880914
• Potapenko et al. (2011) Inhibitory-excitatory synaptic balance is shifted toward increased excitation in magnocellular neurosecretory cells of heart failure rats. J Neurophysiol. 106:1545
  PMID: 21697450
• Hisadome et al. (2011) CCK stimulation of GLP-1 neurons involves α1-adrenoceptor-mediated increase in glutamatergic synaptic inputs. Diabetes. 60:2701
  PMID: 21885869
• Schmidt and Kofuji (2011) Structure and function of bistratified intrinsically photosensitive retinal ganglion cells in the mouse. J Comp Neurol. 519:1492
  PMID: 21452206
• Zheng and Raman (2011) Prolonged postinhibitory rebound firing in the cerebellar nuclei mediated by group I metabotropic glutamate receptor potentiation of L-type calcium currents. J Neurosci. 31:10283
  PMID: 21753005
• Reali et al. (2011) GABAergic signalling in a neurogenic niche of the turtle spinal cord. J Physiol. 589:5633
  PMID: 21911613
• Schnell et al. (2011) Determinants of functional coupling between astrocytes and respiratory neurons in the pre-Bötzinger complex. PLoS One. 6:e26309
  PMID: 22039458
• Ripley et al. (2011) Regulation of synaptic stability by AMPA receptor reverse signaling. Proc Natl Acad Sci U S A. 108:367
  PMID: 21173224
• Crosby et al. (2011) Endocannabinoids gate state-dependent plasticity of synaptic inhibition in feeding circuits. Neuron. 71:529
  PMID: 21835348
• Tang et al. (2011) Neto1 is an auxiliary subunit of native synaptic kainate receptors. J Neurosci. 31:10009
  PMID: 21734292
• Torborg et al. (2010) Control of CA3 output by feedforward inhibition despite developmental changes in the excitation-inhibition balance. J Neurosci. 30:15628
  PMID: 21084618
• Barkis et al. (2010) Non-cell-autonomous factor induces the transition from excitatory to inhibitory GABA signaling in retina independent of activity. Proc Natl Acad Sci U S A. 107:22302
  PMID: 21135238
• Citri et al. (2010) Calcium binding to PICK1 is essential for the intracellular retention of AMPA receptors underlying long-term depression. J Neurosci. 30:16437
  PMID: 21147983
• Olmos-Serrano et al. (2010) Defective GABAergic neurotransmission and pharmacological rescue of neuronal hyperexcitability in the amygdala in a mouse model of fragile X syndrome. J Neurosci. 30:9929
  PMID: 20660275
• Zhang et al. (2010) A p38 mitogen-activated protein kinase-dependent mechanism of disinhibition in spinal synaptic transmission induced by tumor necrosis factor-alpha. J Neurosci. 30:12844
  PMID: 20861388
• Wamsteeker et al. (2010) Repeated stress impairs endocannabinoid signaling in the paraventricular nucleus of the hypothalamus. J Neurosci. 30:11188
  PMID: 20720126
• Stevens et al. (2010) Light-evoked NMDA receptor-mediated currents are reduced by blocking D-serine synthesis in the salamander retina. Neuroreport. 21:239
  PMID: 20101193
• Rinetti and Schweizer (2010) Ubiquitination acutely regulates presynaptic neurotransmitter release in mammalian neurons. J Neurosci. 30:3157
  PMID: 20203175
• Kramár et al. (2009) Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity. J Neurosci. 29:12982
  PMID: 19828812
• Citri et al. (2009) N-MthD.-aspartate receptor- and metabotropic glutamate receptor-dependent long-term depression are differentially regulated by the ubiquitin-proteasome system. Eur J Neurosci. 30:1443
  PMID: 19821836
• Fan and Cooper (2009) Glutamate-induced NFκB activation in the retina. Invest Ophthalmol Vis Sci. 50:917
  PMID: 18836176
• Schmidt and Kofuji (2009) Functional and morphological differences among intrinsically photosensitive retinal ganglion cells. J Neurosci. 29:476
  PMID: 19144848
• Llano et al. (2009) Rapid and sensitive mapping of long-range connections in vitro using flavoprotein autofluorescence imaging combined with laser photostimulation. J Neurophysiol. 101:3325
  PMID: 19321634
• Terunuma et al. (2008) Deficits in phosphorylation of GABA(A) receptors by intimately associated protein kinase C activity underlie compromised synaptic inhibition during status epilepticus. J Neurosci. 28:376
  PMID: 18184780
• Krook-Magnuson et al. (2008) Tonically active inhibition selectively controls feedforward circuits in mouse barrel cortex. J Neurophysiol. 100:932
  PMID: 18509076
• Jüngling et al. (2008) Neuropeptide S-mediated control of fear expression and extinction: role of intercalated GABAergic neurons in the amygdala. Neuron. 59:298
  PMID: 18667157
• Safiulina et al. (2008) Low expression of Kv7/M channels facilitates intrinsic and network bursting in the developing rat hippocampus. J Physiol. 586:5437
  PMID: 18801845
• Guitton and Dudai (2008) Blockade of cochlear NMDA receptors prevents long-term tinnitus during a brief consolidation window after acoustic trauma. Neural Plast. 2007:80904
  PMID: 18301716
• Molineux et al. (2008) Ionic factors governing rebound burst phenotype in rat deep cerebellar neurons. J Neurophysiol. 100:2684
  PMID: 18768644
• Furness et al. (2008) A quantitative assessment of glutamate uptake into hippocampal synaptic terminals and astrocytes: new insights into a neuronal role for excitatory amino acid transporter 2 (EAAT2). Neuroscience. 157:80
  PMID: 18805467
• Biou et al. (2008) Endocytosis and recycling of AMPA receptors lacking GluR2/3. Proc Natl Acad Sci U S A. 105:1038
  PMID: 18195348
• Chen et al. (2007) Changes in synaptic morphology accompany actin signaling during LTP. J Neurosci. 27:5363
  PMID: 17507558
• Ting et al. (2007) Amyloid precursor protein overexpression depresses excitatory transmission through both presynaptic and postsynaptic mechanisms. Proc Natl Acad Sci U S A. 104:353
  PMID: 17185415
• Young et al. (2007) Glutamate receptor expression and chronic glutamate toxicity in rat motor cortex. Neurobiol Dis. 26:78
  PMID: 17240155
• Jara et al. (2007) Tumor necrosis factor α stimulates NMDA receptor activity in mouse cortical neurons resulting in ERK-dependent death. J Neurochem. 100:1407
  PMID: 17241124
• Marsden et al. (2007) NMDA receptor activation potentiates inhibitory transmission through GABA receptor-associated protein-dependent exocytosis of GABA(A) receptors. J Neurosci. 27:14326
  PMID: 18160640
• Singh et al. (2006) Altered balance of glutamatergic/GABAergic synaptic input and associated changes in dendrite morphology after BDNF expression in BDNF-deficient hippocampal neurons. J Neurosci. 26:7189
  PMID: 16822976
• Perez-Leon et al. (2006) Synaptic inputs to retinal ganglion cells that set the circadian clock. Eur J Neurosci. 24:1117
  PMID: 16930437
• Kopp et al. (2006) Insufficient sleep reversibly alters bidirectional synaptic plasticity and NMDA receptor function. J Neurosci. 26:12456
  PMID: 17135407
• Ince-Dunn et al. (2006) Regulation of thalamocortical patterning and synaptic maturation by NeuroD2. Neuron. 49:683
  PMID: 16504944
• Haj-Dahmane (2005) The wake-promoting peptide orexin-B inhibits glutamatergic transmission to dorsal raphe nucleus serotonin neurons through retrograde endocannabinoid signaling. J Neurosci. 25:896
  PMID: 15673670
• Shleper et al. (2005) D-serine is the dominant endogenous coagonist for NMDA receptor neurotoxicity in organotypic hippocampal slices. J Neurosci. 25:9413
  PMID: 16221850
• Jacob et al. (2005) Signaling microdomains regulate inositol 1,4,5-trisphosphate-mediated intracellular calcium transients in cultured neurons. J Neurosci. 25:2853
  PMID: 15772345
• Faria (2004) Protective effect of ifenprodil against spreading depression in the mouse entorhinal cortex. J Neurophysiol. 92:2610
  PMID: 15201313
• Fujino and Oertel (2003) Bidirectional synaptic plasticity in the cerebellum-like mammalian dorsal cochlear nucleus. Proc Natl Acad Sci U S A. 100:265
  PMID: 12486245
• Min et al. (1999) Synaptically released glutamate reduces gamma-aminobutyric acid (GABA)ergic inhibition in the hippocampus via kainate receptors. Proc Natl Acad Sci U S A. 96:9932
  PMID: 10449797
• Fedele and Raiteri (1996) Desensitization of AMPA receptors and AMPA-NMDA receptor interaction: an in vivo cyclic GMP microdialysis study in rat cerebellum. Br J Pharmacol. 117:1133
  PMID: 8882607
• Lafourcade et al. Molecular components and functions of the endocannabinoid system in mouse prefrontal cortex. PLoS One. 2:e709
  PMID: 17684555

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• Block of AMPAR sIPSCs

  Name: Anonymous
  Species: Human
  Assay Type: Ex Vivo
  Cell Line/Tissue: Stem cell - derived neurons
  DNQX was used to block spontaneous AMPA-receptor – generated excitatory post-synaptic currents (EPSCs) in stem-cell derived cultured dopamine neurons. 20 µM DNQX fully suppressed EPSC propagation, thus confirming the compound's specificity (see illustration). Preparation of 10 mM DMSO stock requires long sonication; in all other respects it is a perfect AMPA-receptor antagonist.
  Reference
  

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