DNQX disodium salt
Tocris Bioscience, part of Bio-Techne | Catalog # 2312
Selective non-NMDA iGluR antagonist; water-soluble salt of DNQX (Cat. No. 0189)
Key Product Details
Description
Selective non-NMDA iGluR antagonist; water-soluble salt of DNQX (Cat. No. 0189)
Product Description
DNQX disodium salt is a more water-soluble form of DNQX (Cat. No. 0189). DNQX is a selective non-NMDA glutamate receptor antagonist. (IC50 = 0.1 μM and 0.5 μM for kainate and AMPA receptors, respectively). DNQX is a neuroleptic agent that shows pro-oxidative properties. DNQX selectively depolarizes rat thalamic reticular nucleus neurons.Product Specifications
Molecular Weight
296.10
Formula
C8H2N4O6Na2
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
6,7-Dinitroquinoxaline-2,3-dione disodium salt
CAS Number
1312992-24-7
PubChem ID
45073428
InChI Key
GPSBSOYURFUVKJ-UHFFFAOYSA-L
SMILES
[Na+].[Na+].[O-]C1=C([O-])N=C2C=C(C(=CC2=N1)[N+]([O-])=O)[N+]([O-])=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 31.4 | 100 |
Preparing Stock Solutions
for DNQX disodium salt
The following data is based on the product molecular weight 296.10
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.38 mL | 16.89 mL | 33.77 mL |
| 5 mM | 0.68 mL | 3.38 mL | 6.75 mL |
| 10 mM | 0.34 mL | 1.69 mL | 3.38 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.68 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Lee Selective excitatory actions of DNQX and CNQX in rat thalamic neurons. J.Neurophysiol. 2010 PMID: 20107128
- Watkins Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists. TiPS 1990 PMID: 2155495
- Šarlauskas Redox properties and prooxidant cytotoxicity of a neuroleptic agent 6,7-dinitrodihydroquinoxaline-2,3-dione (DNQX) Acta Biochim.Pol. 2013 PMID: 23757451
- Honore Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. Science 1988 PMID: 2899909
Product Specific Notices for DNQX disodium salt
For research use only
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