Key Product Details
Description: | Selective non-transportable inhibitor of EAATs |
Chemical Name: | DL-threo-β-Benzyloxyaspartic acid |
Purity: | ≥98% (HPLC) |
Molecular Weight: | 239.23 |
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Citations for DL-TBOA (58)
Citations are publications that use Bio-Techne products. Selected citations for DL-TBOA include:
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Woo et al.
(2019)
Pharmacological Dissection of Intrinsic Optical Signal Reveals a Functional Coupling between Synaptic Activity and Astrocytic Volume Transient.
Exp Neurobiol.
28:30
PMID: 30853822 -
Zhang et al.
(2019)
Role of intraganglionic transmission in the trigeminovascular pathway.
Mol Pain.
15:1744806919836570
PMID: 30784351 -
Styr et al.
(2019)
Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility.
Neuron.
102:1009
PMID: 31047779 -
Romanos et al.
(2019)
Differences in glutamate uptake between cortical regions impact neuronal NMDA receptor activation.
Commun Biol.
2:127
PMID: 30963115 -
Falcucci et al.
(2019)
Novel positive allosteric modulators of glutamate transport have neuroprotective properties in an in vitro excitotoxic model.
ACS Chem Neurosci.
10:3437
PMID: 31257852 -
Piccirillo et al.
(2018)
Glutamate as a potential "survival factor" in an in vitro model of neuronal hypoxia/reoxygenationinjury: leading role of the Na+/Ca2+ exchanger.
Cell Death Dis.
9(7):731
PMID: 29955038 -
Thalman et al.
(2018)
Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders.
Mol Psychiatry.
23(8):1699
PMID: 29743582 -
Tchernookova et al.
(2018)
Activation of retinal glial (M�ller) cells by extracellular ATP induces pronounced increases in extracellular H+ flux.
PLoS One.
13:e0190893
PMID: 29466379 -
Vincent et al.
(2018)
Clustered Ca2+ Channels Are Blocked by Synaptic Vesicle Proton Release at Mammalian Auditory Ribbon Synapses.
Cell Rep.
25:3451
PMID: 30566869 -
Rossi
(2018)
Pre- and postsynaptic effects of glutamate in the frog labyrinth.
Neuroscience.
385:198
PMID: 29913242 -
Brancaccio et al.
(2017)
Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling.
Neuron.
93:1420
PMID: 28285822 -
Agarwal et al.
(2017)
Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes.
Neuron.
93:587
PMID: 28132831 -
Lu et al.
(2017)
Slow AMPAR Synaptic Transmission Is Determined by Stargazin and Glutamate Transporters.
Neuron.
96:73
PMID: 28919175 -
Sloan et al.
(2017)
Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells.
Neuron.
95:779
PMID: 28817799 -
Romei et al.
(2016)
Colocalization of neurotransmitter transporters on the plasma membrane of the same nerve terminal may reflect cotransmission.
Brain Research Bulletin.
127:100
PMID: 27565422 -
Griffin et al.
(2015)
Repeated cycles of chronic intermittent ethanol exposure increases basal glutamate in the nucleus accumbens of mice without affecting glutamate transport.
Front Pharmacol.
6:27
PMID: 25755641 -
Lin et al.
(2015)
Palmitoylethanolamide inhibits glutamate release in rat cerebrocortical nerve terminals.
Elife.
16:5555
PMID: 25768340 -
Rosa et al.
(2015)
Neuron-glia signaling in developing retina mediated by neurotransmitter spillover.
J Neurosci.
4
PMID: 26274565 -
Campbell et al.
(2015)
Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasia.
BMC Cancer.
8:425
PMID: 25565960 -
Pedraz-Cuesta et al.
(2015)
The glutamate transport inhibitor DL-Threo-β-Benzyloxyaspartic acid (DL-TBOA) differentially affects SN38- and oxaliplatin-induced death of drug-resistant colorectal cancer cells.
J Neurosci.
15:411
PMID: 25981639 -
Petr et al.
(2015)
Conditional deletion of the glutamate transporter GLT-1 reveals that astrocytic GLT-1 protects against fatal epilepsy while neuronal GLT-1 contributes significantly to glutamate uptake into synaptosomes.
Sci Rep.
35:5187
PMID: 25834045 -
Kuebler et al.
(2015)
Burst predicting neurons survive an in vitro glutamate injury model of cerebral ischemia.
J Neurosci.
5:17718
PMID: 26648112 -
Vance et al.
(2015)
PAR1-activated astrocytes in the nucleus of the solitary tract stimulate adjacent neurons via NMDA receptors.
J Neurosci.
35:776
PMID: 25589770 -
Megill et al.
(2015)
Defective Age-Dependent Metaplasticity in a Mouse Model of Alzheimer's Disease.
Nat Protoc.
35:11346
PMID: 26269641 -
Huang et al.
(2015)
Acidosis-Induced Dysfunction of Cortical GABAergic Neurons through Astrocyte-Related Excitotoxicity.
Invest Ophthalmol Vis Sci.
10:e0140324
PMID: 26474076 -
Falgairolle and O'Donovan
(2015)
Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons.
J Neurosci.
10:e0131430
PMID: 26102354 -
Pedraz-Cuesta et al.
(2015)
The glutamate transport inhibitor DL-Threo--Benzyloxyaspartic acid (DL-TBOA) differentially affects SN38- and oxaliplatin-induced death of drug-resistant colorectal cancer cells.
BMC Cancer.
15:411
PMID: 25981639 -
Cengiz et al.
(2014)
Sustained Na+/H+ exchanger activation promotes gliotransmitter release from reactive hippocampal astrocytes following oxygen-glucose deprivation.
PLoS One.
9:e84294
PMID: 24392123 -
Liang et al.
(2014)
δ-Opioid receptors up-regulate excitatory amino acid transporters in mouse astrocytes.
Vision Res.
171:5417
PMID: 25052197 -
Tse et al.
(2014)
Possible roles of glutamate transporter EAAT5 in mouse cone depolarizing bipolar cell light responses.
Vision Res.
103:63
PMID: 24972005 -
Tse et al.
(2014)
Pharmacological inhibitions of glutamate transporters EAAT1 and EAAT2 compromise glutamate transport in photoreceptor to ON-bipolar cell synapses.
J Neurophysiol.
103:49
PMID: 25152321 -
Armbruster et al.
(2014)
Laser-scanning astrocyte mapping reveals increased glutamate-responsive domain size and disrupted maturation of glutamate uptake following neonatal cortical freeze-lesion.
Front Cell Neurosci.
8:277
PMID: 25249939 -
Zhou et al.
(2014)
Cerebellar modules operate at different frequencies.
Elife.
3:e02536
PMID: 24843004 -
Tovar-y-Romo et al.
(2013)
Adenosine triphosphate released from HIV-infected macrophages regulates glutamatergic tone and dendritic spine density on neurons.
J Neuroimmune Pharmacol.
8:998
PMID: 23686368 -
Jeon et al.
(2013)
Presynaptic Localization and Possible Function of Calcium-Activated Chloride Channel Anoctamin 1 in the Mammalian Retina.
PLoS One.
8:e67989
PMID: 23840801 -
Georgieva et al.
(2013)
Conformational ensemble of the sodium-coupled aspartate transporter.
Nat Struct Mol Biol.
20:215
PMID: 23334289 -
He et al.
(2013)
Synaptic and extrasynaptic plasticity in glutamatergic circuits involving dentate granule cells following chronic N-MthD.-aspartate receptor inhibition.
Int J Mol Sci.
109:1535
PMID: 23255721 -
McCall et al.
(2013)
Fabrication and application of flexible, multimodal light-emitting devices for wireless optogenetics.
Sci Signal.
8:2413
PMID: 24202555 -
Koeglsperger et al.
(2013)
Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-β1 in the CNS.
Glia.
61:985
PMID: 23536313 -
Wang et al.
(2012)
Astrocytes modulate neural network activity by Ca2+-dependent uptake of extracellular K+.
PLoS One.
5:ra26
PMID: 22472648 -
Ichinose and Lukasiewicz
(2012)
The mode of retinal presynaptic inhibition switches with light intensity.
J Neurosci.
32:4360
PMID: 22457487 -
Jarzylo and Man
(2012)
Parasynaptic NMDA receptor signaling couples neuronal glutamate transporter function to AMPA receptor synaptic distribution and stability.
J Neurosci.
32:2552
PMID: 22396428 -
Yoshizumi et al.
(2012)
R.zole and gabapentinoids activate glutamate transporters to facilitate glutamate-induced glutamate release from cultured astrocytes.
Eur J Pharmacol.
677:87
PMID: 22206816 -
Zou et al.
(2011)
Morphine potentiates neurodegenerative effects of HIV-1 Tat through actions at μ-opioid receptor-expressing glia.
Brain.
134:3616
PMID: 22102648 -
Vandenberg et al.
(2011)
Water and urea permeation pathways of the human excitatory amino acid transporter EAAT1.
Biochem J.
439:333
PMID: 21732909 -
Maurer et al.
(2010)
Distinct retinal deficits in a zebrafish pyruvate dehydrogenase-deficient mutant.
J Neurosci.
30:11962
PMID: 20826660 -
Mohr et al.
(2010)
Young age and low temperature, but not female gender delay ATP loss and glutamate release, and protect Purkinje cells during simulated ischemia in cerebellar slices.
Neuropharmacology.
58:392
PMID: 19825379 -
Biase et al.
(2010)
Excitability and synaptic communication within the oligodendrocyte lineage.
Front Cell Neurosci.
30:3600
PMID: 20219994 -
Mulholland and Chandler
(2010)
Inhibition of glutamate transporters couples to Kv4.2 dephosphorylation through activation of extrasynaptic NMDA receptors.
PLoS One.
165:130
PMID: 19850106 -
Krock et al.
(2009)
Retrograde intraflagellar transport by cytoplasmic dynein-2 is required for outer segment extension in vertebrate photoreceptors but not arrestin translocation.
Invest Ophthalmol Vis Sci.
50:5463
PMID: 19474410 -
Costa et al.
(2008)
Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition.
J Neurosci.
28:8040
PMID: 18685029 -
Léveillé et al.
(2008)
Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors.
FASEB J.
22:4258
PMID: 18711223 -
Baltan et al.
(2008)
White matter vulnerability to ischemic injury increases with age because of enhanced excitotoxicity.
Br J Pharmacol.
28:1479
PMID: 18256269 -
Stridh et al.
(2008)
Stimulated efflux of amino acids and glutathione from cultured hippocampal slices by omission of extracellular calcium: likely involvement of connexin hemichannels.
J Biol Chem.
283:10347
PMID: 18272524 -
Duguid et al.
(2007)
Somatodendritic release of glutamate regulates synaptic inhibition in cerebellar Purkinje cells via autocrine mGluR1 activation.
J Neurosci.
27:12464
PMID: 18003824 -
Bender et al.
(2006)
Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex.
J Neurosci.
26:4166
PMID: 16624937 -
Matsui et al.
(2006)
Effects of ethanol on photoreceptors and visual function in developing zebrafish.
J Neurosci.
47:4589
PMID: 17003456 -
Yang et al.
(2005)
Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake.
Neuroscience.
25:4288
PMID: 15858055
There are no citations that match your criteria.
Customer Reviews for DL-TBOA (1)
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Species: MouseAssay Type: In VitroCell Line/Tissue: Mixed neuron-gliaTBOA (100 μM)Incubate for 24h
There are no reviews that match your criteria.