Dexrazoxane hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 3857
Topoisomerase II inhibitor
Key Product Details
Description
Topoisomerase II inhibitor
Alternative Names
ICRF-187
Product Description
Dexrazoxane hydrochloride is a topoisomerase II inhibitor and intracellular ion chelator. Bridges and stabilizes an interface between two ATPase promoters to inhibit topoisomerase II activity. Cardioprotective when co-administered with doxorubicin; decreases formation of reactive oxygen species (ROS) and activates the PI3K/Akt survival pathway.Product Specifications
Molecular Weight
304.73
Formula
C11H16N4O4.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
4-[(2S)-2-(3,5-Dioxopiperazin-1-yl)propyl]piperazine-2,6-dione hydrochloride
CAS Number
1263283-43-7
PubChem ID
6918223
InChI Key
BIFMNMPSIYHKDN-FJXQXJEOSA-N
SMILES
C[C@@H](CN2CC(NC(C2)=O)=O)N(CC(N1)=O)CC1=O.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 30.47 | 100 | |
| DMSO | 30.47 | 100 |
Preparing Stock Solutions
for Dexrazoxane hydrochloride
The following data is based on the product molecular weight 304.73
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.28 mL | 16.41 mL | 32.82 mL |
| 5 mM | 0.66 mL | 3.28 mL | 6.56 mL |
| 10 mM | 0.33 mL | 1.64 mL | 3.28 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.66 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Spallarossa Sublethal doses of an anti-erbB2 antibody leads to death by apoptosis in cardiomyocytes sensitized by low prosenescent doses of epirubicin: the protective role of dexraz. J.Pharmacol.Exp.Ther. 2010 PMID: 19841470
- Classen Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187. Proc.Natl.Acad.Sci.
- Lebrecht Dexrazoxane prevents doxorubicin-induced long-term cardiotoxicity and protects myocardial mitochondria from genetic and functional lesions in rats. Br.J.Pharmacol 2007 PMID: 17519947
Product Specific Notices for Dexrazoxane hydrochloride
For research use only
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