[D-Ala²]-GIP (human)

Name: [D-Ala 2 ]-GIP (human)
Brand: Tocris Bioscience
SKU: 6699

Tocris Bioscience a Bio-Techne Brand

Catalog # 6699

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Key Product Details

Description:	Highly potent GIP agonist
Purity:	≥95% (HPLC)
Molecular Weight:	4983.58

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Biological Activity for [D-Ala²]-GIP (human)

[D-Ala²]-GIP (human) is a highly potent GIP receptor agonist (EC₅₀ = 630 ± 119 pM). Displays equivalent cAMP stimulating properties and improved resistance to enzymatic degradation compared to native GIP (Cat. No. 2084) in cells expressing wild type GIP receptor. Improves glucose tolerance, insulin release and cognitive function in various animal models of obesity and diabetes. Displays neuroprotective effects in an MPTP model of PD.

Technical Data for [D-Ala²]-GIP (human)

M. Wt	4983.58
Formula	C₂₂₆H₃₃₈N₆₀O₆₆S
Single Letter Sequence	YAEGTFISDYSIAMDKIHQQDFVNWLLAQKGKKNDWKHNITQ (Modifications: Ala-2 = D-Ala)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	444073-04-5
Smiles	[H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for [D-Ala²]-GIP (human)

Solubility

Soluble to 1mg/ml in water

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References for [D-Ala²]-GIP (human)

References are publications that support the biological activity of the product.

Verma Effect of D-Ala²GIP, a stable GIP receptor agonist on MPTP-induced neuronal impairments in mice. Eur.J.Pharmacol. 2017 PMID: 28366809
Porter Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high-fat fed mice. Eur.J.Pharmacol. 2011 PMID: 21050845
Hinke Dipeptidyl peptidase IV-resistant [D-Ala²]glucose-dependent Insotropic polypeptide (GIP) improves glucose tolerance in normal and obese diabetic rats. Diabetes. 2002 PMID: 11872663

Citations for [D-Ala²]-GIP (human)

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[D-Ala²]-GIP (human)

Tocris Bioscience a Bio-Techne Brand

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Biological Activity for [D-Ala²]-GIP (human)

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References for [D-Ala²]-GIP (human)

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[D-Ala2]-GIP (human)

Tocris Bioscience a Bio-Techne Brand

Key Product Details

Complete Your Research

Biological Activity for [D-Ala2]-GIP (human)

Technical Data for [D-Ala2]-GIP (human)

Solubility for [D-Ala2]-GIP (human)

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for [D-Ala2]-GIP (human)

Citations for [D-Ala2]-GIP (human)

Product Documents for [D-Ala2]-GIP (human)

COA

Certificate of Analysis

SDS

Bio-Techne Brands

[D-Ala²]-GIP (human)

Biological Activity for [D-Ala²]-GIP (human)

Technical Data for [D-Ala²]-GIP (human)

Solubility for [D-Ala²]-GIP (human)

References for [D-Ala²]-GIP (human)

Citations for [D-Ala²]-GIP (human)

Product Documents for [D-Ala²]-GIP (human)