CPCCOEt
Tocris Bioscience, part of Bio-Techne | Catalog # 1028
Selective non-competitive mGlu1 antagonist
Key Product Details
Description
Selective non-competitive mGlu1 antagonist
Product Description
CPCCOEt is a hmGlu1 subtype-selective non-competitive antagonist (IC50 = 6.5 μM). Has no agonist or antagonist activity at hmGlu2, 4a, 5a, 7b, 8a or ionotropic receptors at concentrations of up to 100 μM.Licensing Information
Sold for research purposes under license from Suntory Ltd.Product Specifications
Molecular Weight
247.25
Formula
C13H13NO4
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
7-(Hydroxyimino)cyclopropa[b]chromen-1a-carboxylate ethyl ester
CAS Number
179067-99-3
PubChem ID
6278000
InChI Key
FXCTZFMSAHZQTR-KAMYIIQDSA-N
SMILES
O=C(OCC)C3(C2C3)OC1=CC=CC=C1/C2=N/O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.73 | 100 |
Preparing Stock Solutions
for CPCCOEt
The following data is based on the product molecular weight 247.25
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.04 mL | 20.22 mL | 40.44 mL |
| 5 mM | 0.81 mL | 4.04 mL | 8.09 mL |
| 10 mM | 0.40 mL | 2.02 mL | 4.04 mL |
| 50 mM | 0.08 mL | 0.40 mL | 0.81 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Litschig CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding. Mol.Pharmacol. 1999 PMID: 10051528
- Annoura A novel class of antagonists for metabotropic glutamate receptors, 7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxylates. Bioorg.Med.Chem.Lett.
- Hermans Reversible and non-competitive antagonist profile of CPCCOEt at the human type 1α metabotropic glutamate receptor. Neuropharmacology 1998 PMID: 9886688
Product Specific Notices for CPCCOEt
For research use only
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