CNQX disodium salt

Name: CNQX disodium salt
Brand: Tocris Bioscience
SKU: 1045
Rating: 4 (3 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 1045

Citations (36)

(3)

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Key Product Details

Description:	Potent non-NMDA iGluR antagonist; more water soluble form of CNQX (Cat. No. 0190)
Chemical Name:	6-Cyano-7-nitroquinoxaline-2,3-dione disodium
Purity:	≥99% (HPLC)
Molecular Weight:	276.12

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Biological Activity for CNQX disodium salt

CNQX disodium salt is a more water-soluble disodium salt of the AMPA and kainate antagonist CNQX (Cat. No. 0190), which is an AMPA and kainate receptor antagonist (IC₅₀ values are 0.3 μM, 1.5 μM for AMPA and kainate receptors, respectively). CNQX is also an antagonist at the glycine modulatory site on the NMDA receptor complex (IC₅₀ = 25 μM). CNQX can be used to isolate GABA_A receptor mediated spontaneous inhibitory postsynaptic currents and antagonizes non-NMDA receptor-mediated responses in cultured cerebellar granule cells. CNQX shows neuroprotective effects in models of ischemia and inhibits seizure-like activity in hippocampal neurons.

Technical Data for CNQX disodium salt

M. Wt	276.12
Formula	C₉H₂N₄O₄Na₂
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	479347-85-8
PubChem ID	2821
InChi Key	YCXDDPGRZKUGDG-UHFFFAOYSA-L
Smiles	[Na+].[Na+].[O-]C1=C([O-])N=C2C=C(C(=CC2=N1)C#N)[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CNQX disodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	5.52	20

Preparing Stock Solutions for CNQX disodium salt

The following data is based on the product molecular weight 276.12.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	18.11 mL	90.54 mL	181.08 mL
1 mM	3.62 mL	18.11 mL	36.22 mL
2 mM	1.81 mL	9.05 mL	18.11 mL
10 mM	0.36 mL	1.81 mL	3.62 mL

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References for CNQX disodium salt

References are publications that support the biological activity of the product.

King Antagonism of synaptic potentials in ventral horn neurones by 6-cyano-7-nitroquinoxaline-2,3-dione: a study in the rat spinal cord in vitro. Br.J.Pharmacol. 1992 PMID: 1358390
Long Effect of 6-cyano-2,3-dihydroxy-7-nitro-quinoxaline (CNQX) on dorsal root-, NMDA-, kainate and quisqualate-mediated depolarization of rat motoneurones in vitro. Br.J.Pharmacol. 1990 PMID: 1976402
Watkins Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists. TiPS 1990 PMID: 2155495
Honore Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. Science 1988 PMID: 2899909

Citations for CNQX disodium salt (36)

Showing 1 - 10 of 36 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for CNQX disodium salt include:

Evans et al. (2020) Functional Dissection of Basal Ganglia Inhibitory Inputs onto Substantia Nigra Dopaminergic Neurons. Cell Rep. 32
PMID: 32937133
Pati et al. (2020) Chronic postnatal chemogenetic activation of forebrain excitatory neurons evokes persistent changes in mood behavior Elife. 9
PMID: 32955432
He et al. (2020) Nucleus Accumbens Tac1-Expressing Neurons Mediate Stress-Induced Anhedonia-like Behavior in Mice. Cell Rep. 33
PMID: 33147466
Green and Thayer et al. (2019) HIV gp120 upregulates tonic inhibition through α5-containing GABA_ARs. Neuropharmacology. 149:161
PMID: 30797029
Spoljaric et al. (2019) KCC2-Mediated Cl- Extrusion Modulates Spontaneous Hippocampal Network Events in Perinatal Rats and Mice. Cell Rep. 26:1073
PMID: 30699338
Gutzmann et al. (2019) Functional Coupling of Cav2.3 and BK Potassium Channels Regulates Action Potential Repolarization and Short-Term Plasticity in the Mouse Hippocampus. Front Cell Neurosci. 13:27
PMID: 30846929
Styr et al. (2019) Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility. Neuron. 102:1009
PMID: 31047779
Kiritoshi and Neugebauer (2018) Pathway-specific alterations of cortico-amygdala transmission in an arthritis pain model. ACS Chem Neurosci. 9:2252
PMID: 29630339
Riquelme et al. (2018) Subcellular Localization and Activity of TRPM4 in Medial Prefrontal Cortex Layer 2/3. Front Cell Neurosci. 12:12
PMID: 29440991
Grillo et al. (2018) A Distance-Dependent Distribution of Presynaptic Boutons Tunes Frequency-Dependent Dendritic Integration. Neuron. 99:275
PMID: 29983327
Leroy et al. (2018) A circuit from hippocampal CA2 to lateral septum disinhibits social aggression. Nature. 564:213
PMID: 30518859
Jalalvand et al. (2018) Cerebrospinal Fluid-Contacting Neurons Sense pH Changes and Motion in the Hypothalamus. J Neurosci. 38:7713
PMID: 30037834
Yuan et al. (2018) A role for proteolytic regulation of δ-catenin in remodeling a subpopulation of dendritic spines in the rodent brain. J Biol Chem. 293:11625
PMID: 29875160
Doshina et al. (2017) Cortical cells reveal APP as a new player in the regulation of GABAergic neurotransmission. Sci Rep. 7:370
PMID: 28337033
Athilingam et al. (2017) Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons. Elife. 6
PMID: 29206101
Chaffiol et al. (2017) A New Promoter Allows Optogenetic Vision Restoration with Enhanced Sensitivity in Macaque Retina. Mol Ther. 25:2546
PMID: 28807567
Sternfeld et al. (2017) Speed and segmentation control mechanisms characterized in rhythmically-active circuits created from spinal neurons produced from genetically-tagged embryonic stem cells. Elife. 6
PMID: 28195039
Medrihan et al. (2017) Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate Gyrus. Neuron. 95:564
PMID: 28735749
Maschi and Klyachko (2017) Spatiotemporal Regulation of Synaptic Vesicle Fusion Sites in Central Synapses. Neuron. 94:65
PMID: 28343869
Paul et al. (2017) Transcriptional Architecture of Synaptic Communication Delineates GABAergic Neuron Identity. Cell. 171:522
PMID: 28942923
Edwards et al. (2017) Comparison of NMDA and AMPA Channel Expression and Function between Embryonic and Adult Neurons Utilizing Microelectrode Array Systems. ACS Biomater Sci Eng. 3:3525
PMID: 29250595
Philippart et al. (2016) Differential Somatic Ca2+ Channel Profile in Midbrain DArgic Neurons The Journal of Neuroscience. 6:7234
PMID: 27383597
Piet et al. (2016) Vasoactive Intestinal Peptide Excites GnRH Neurons in Male and Female Mice. Endocrinology.. 157:3621
PMID: 27501185
Cazares et al. (2016) Dynamic Partitioning of Synaptic Vesicle Pools by the SNARE-Binding Protein Tomosyn. J Neurosci. 36:11208
PMID: 27807164
Li et al. (2016) A Cortical Circuit for Sexually Dimorphic Oxytocin-Dependent Anxiety Behaviors. Cell. 167:60
PMID: 27641503
Mauger et al. (2016) Targeted Intron Retention and Excision for Rapid Gene Regulation in Response to Neuronal Activity. Neuron. 92:1266
PMID: 28009274
Baltz and Voigt (2015) Interaction of electrically evoked activity with intrinsic dynamics of cultured cortical networks with and without functional fast GABAergic synaptic transmission. Front Cell Neurosci. 9:272
PMID: 26236196
Schitine et al. (2015) Functional plasticity of GAT-3 in avian Müller cells is regulated by neurons via a glutamatergic input. J Neurosci. 82:42
PMID: 25700791
Zhao et al. (2015) Extracellular glutamate exposure facilitates group I mGluR-mediated epileptogenesis in the hippocampus. Neuropsychopharmacology. 35:308
PMID: 25568123
Einarsson et al. (2015) Systems reconsolidation reveals a selective role for the anterior cingulate cortex in generalized contextual fear memory expression. J Endocrinol. 40:480
PMID: 25091528
Schubert et al. (2014) Paraneoplastic CDR2 and CDR2L antibodies affect Purkinje cell calcium homeostasis. Acta Neuropathol. 128:835
PMID: 25341622
Villers et al. (2014) Long-term potentiation can be induced in the CA1 region of hippocampus in the absence of αCaMKII T286-autophosphorylation. Learn Mem. 21:616
PMID: 25322797
Guo et al. (2012) Tissue engineering the monosynaptic circuit of the stretch reflex arc with co-culture of embryonic motoneurons and proprioceptive sensory neurons. Biomaterials. 33:5723
PMID: 22594977
Janssen et al. (2012) Neuregulin directly decreases voltage-gated sodium current in hippocampal ErbB4-expressing interneurons. J Neurosci. 32:13889
PMID: 23035098
Carlson et al. (2012) Pharmacological evidence that D-aspartate activates a current distinct from ionotropic glutamate receptor currents in Aplysia californica. Brain Behav. 2:391
PMID: 22950043
Yuan et al. (2009) The serine protease plasmin cleaves the amino-terminal domain of the NR2A subunit to relieve zinc inhibition of the N-MthD.-aspartate receptors. J Biol Chem. 284:12862
PMID: 19240037

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Antidepressantsby Cholecystokinin Neurons of the Dentate Gyrus

Name: Anonymous

Species: Mouse

Assay Type: In Vivo

30uM CNQX

PMID: 28735749
CNQX as an AMPA antagonist for whole cell recordings

Name: Anonymous

Species: Mouse

Assay Type: Ex Vivo

AMPA antagonist used in whole cell recordings. We made a stock solution at 20mM in water and dilute to 10uM for experiments. EPSCs are wiped out, so this concentration appears effective despite concerns over uniformity.

The stock solution does not look uniform, so we stir it well before diluting to final concentration. In the picture you can see how the drug is coming out of solution (powder on the walls of the vial).
CNQX

Name: Anonymous

Species: Rat

Assay Type: Ex Vivo

AMPA receptor antagonist used at 20uM in rat brain slice

Stock solution is little sticky. Voltex well before making dilution.

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