Potent and selective non-NMDA iGluR antagonist
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Key Product Details
Description: | Potent and selective non-NMDA iGluR antagonist |
Alternative Names: | Cyanquixaline |
Chemical Name: | 6-Cyano-7-nitroquinoxaline-2,3-dione |
Purity: | ≥99% (HPLC) |
Molecular Weight: | 232.16 |
Citations for CNQX (214)
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Woo et al.
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Differences in glutamate uptake between cortical regions impact neuronal NMDA receptor activation.
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TRPC3 channels critically regulate hippocampal excitability and contextual fear memory.
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Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss.
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Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons.
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Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3).
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Front Cell Neurosci.
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Sengupta and Thirumalai
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AMPA receptor mediated synaptic excitation drives state-dependent bursting in Purkinje neurons of zebrafish larvae.
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4
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Qiu et al.
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GluA1 phosphorylation contributes to postsynaptic amplification of neuropathic pain in the insular cortex.
J Neurosci.
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Species: RatAssay Type: Ex VivoCell Line/Tissue: Anterior singulate cortexCNQX was used to study input of non-NMDA glutamate receptors into short-term plasticity in anterior cingulate cortex. Being applied in 5 microM concentration, CNQX reduced significantly both amplitudes of field potentials and their paired-pulse ratio.
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