Clemastine fumarate
Tocris Bioscience, part of Bio-Techne | Catalog # 1453
H1 antagonist
Product Description
Clemastine fumarate is a h1-receptor antagonist. Enhances differentiation of oligodendrocyte progenitor cells into myelin basic protein-positive oligodendrocytes in vitro and promotes remyelination in vivo. Also displays antimuscarinic properties. Clinically-used antihistamine.Product Specifications
Molecular Weight
459.97
Formula
C21H26ClNO.C4H4O4
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
(2R)-2-[2-[(1R)-1-(4-Chlorophenylethoxy]ethyl]-1-methyl-2-pyrrolidine fumarate
CAS Number
14976-57-9
PubChem ID
5281069
InChI Key
PMGQWSIVQFOFOQ-YKVZVUFRSA-N
SMILES
[H]OC(=O)\C=C\C(=O)O[H].CN1CCC[C@@H]1CCO[C@](C)(C1=CC=CC=C1)C1=CC=C(Cl)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.2 | 20 |
Preparing Stock Solutions
for Clemastine fumarate
The following data is based on the product molecular weight 459.97
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 10.87 mL | 54.35 mL | 108.70 mL |
| 1 mM | 2.17 mL | 10.87 mL | 21.74 mL |
| 2 mM | 1.09 mL | 5.44 mL | 10.87 mL |
| 10 mM | 0.22 mL | 1.09 mL | 2.17 mL |
Calculators
Molarity Calculator
Dilution Calculator
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Background References
References are publications that support the biological activity of the product.
- Hartmann Modulation of histamine-induced bronchoconstriction with inhaled, oral, and intravenous clemastine in normal and asthmatic subjects. Thorax 1981 PMID: 7330790
- Nair and Schwartz Effect of histamine and histamine antagonists on natural and antibody-dependent cellular cytotoxicity of human lymphocytes in vitro. Cell.Immunol. 1983 PMID: 6225527
- Dorsch Histamine1-histamine2 antagonism: effect of combined clemastine and cimetidine pretreatment on allergen and histamine-induced reactions of the guinea pig lung in vivo and in vitro. Agents Actions 1982 PMID: 6177209
Product Specific Notices for Clemastine fumarate
For research use only
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