CK 666

Name: CK 666
Brand: Tocris Bioscience
SKU: 3950

Tocris Bioscience a Bio-Techne Brand

Catalog # 3950

Citations (14)

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Key Product Details

Description:	Arp2/3 inhibitor; inhibits actin polymerization
Chemical Name:	2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide
Purity:	≥99% (HPLC)
Molecular Weight:	296.34

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Biological Activity for CK 666

CK 666 is an inhibitor of the Arp2/3 complex; inhibits actin polymerization (IC₅₀ = 4 μM).

Technical Data for CK 666

M. Wt	296.34
Formula	C₁₈H₁₇FN₂O
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	442633-00-3
PubChem ID	589075
InChi Key	UXRKUKRXVWJFER-UHFFFAOYSA-N
Smiles	FC1=CC=CC=C1C(NCCC2=C(C)NC3=C2C=CC=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CK 666

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	29.63	100
	ethanol	29.63	100

Preparing Stock Solutions for CK 666

The following data is based on the product molecular weight 296.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.37 mL	16.87 mL	33.75 mL
5 mM	0.67 mL	3.37 mL	6.75 mL
10 mM	0.34 mL	1.69 mL	3.37 mL
50 mM	0.07 mL	0.34 mL	0.67 mL

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References for CK 666

References are publications that support the biological activity of the product.

Nolen Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature 2009 PMID: 19648907
Han and Nolen X-ray crystal structures and molecular mechanism of improved Arp2/3 complex inhibitors. 1751 ACSB 2009 Abstracts. American Society for Cel

Citations for CK 666 (14)

Showing 1 - 10 of 14 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for CK 666 include:

Roesler et al. (2019) Myosin XVI Regulates Actin Cytoskeleton Dynamics in Dendritic Spines of Purkinje Cells and Affects Presynaptic Organization. Front Cell Neurosci. 13:330
PMID: 31474830
Yamagashi et al. (2018) Use of CK-548 and CK-869 as Arp2/3 complex inhibitors directly suppresses microtubule assembly both in vitro and in vivo. Biochem Biophys Res Commun. 496:834
PMID: 29395083
Logue et al. (2018) c-Src activity is differentially required by cancer cell motility modes. Oncogene. 37:2104
PMID: 29379163
Tabdanov et al. (2018) Bimodal sensing of guidance cues in mechanically distinct microenvironments. Nat Commun. 9:4891
PMID: 30459308
Tabdanov et al. (2018) Microtubule-Actomyosin Mechanical Cooperation during Contact Guidance Sensing. Cell Rep. 25:328
PMID: 30304674
Sepúlveda-Ramírez et al. (2018) Cdc42 controls primary mesenchyme cell morphogenesis in the sea urchin embryo. Dev Biol. 437:140
PMID: 29555242
Bharadwaj (2017) αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin. Nat Commun. 8:14348
PMID: 28128308
Han et al. (2016) Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation Nature. 539:570
PMID: 27820945
Panousopoulou et al. (2016) Epiboly generates the epidermal basal monolayer and spreads the nascent mammalian skin to enclose the embryonic body. J Cell Sci. 129:1915
PMID: 26989131
Basu et al. (2016) Arp2/3 and VASP Are Essential for Fear Memory Formation in Lateral Amygdala. Eneuro. 3
PMID: 27957528
Tornavaca et al. (2015) ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation. Proc Natl Acad Sci U S A. 208:821
PMID: 25753039
Moreau et al. (2015) Signal strength regulates antigen-mediated T-cell deceleration by distinct mechanisms to promote local exploration or arrest. Nat Commun. 112:12151
PMID: 26371316
Sorce et al. (2015) Mitotic cells contract actomyosin cortex and generate pressure to round against or escape epithelial confinement. Cell Calcium. 6:8872
PMID: 26602832
Dalton and Carroll (2013) Biased inheritance of mitochondria during asymmetric cell division in the mouse oocyte. J Cell Sci. 126:2955
PMID: 23659999

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