CCG 203971

Name: CCG 203971
Brand: Tocris Bioscience
SKU: 5277

Tocris Bioscience, part of Bio-Techne | Catalog # 5277

Citations (6)

COA / SDS

Inhibits the MRTF/SRF gene transcription pathway; antifibrotic agent

Discontinued Product

5277 has been discontinued. View all Additional Transcription Factor Compounds products.

Key Product Details

Description:	Inhibits the MRTF/SRF gene transcription pathway; antifibrotic agent
Chemical Name:	N-(4-Chlorophenyl)-1-[3-(2-furanyl)benzoyl]-3-piperidinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	408.88

View Full Technical Details for CCG 203971

Technical Data
Citations

Biological Activity for CCG 203971

CCG 203971 is an antifibrotic agent; inhibits fibrosis by targeting the MRTF/SRF gene transcription pathway. Selectively inhibits proliferation of SSc-derived dermal fibroblasts but not that of normal fibroblasts. Inhibits expression of CTGF, α-SMA, and COL1A2 in SSc fibroblasts as well as in LPA and in TGFβ-stimulated fibroblasts. Prevents bleomycin-induced skin thickening and collagen deposition in vivo. Also suppresses PC-3 cell migration in scratch wound assays (IC₅₀ = 4.2 μM).

Technical Data for CCG 203971

M. Wt	408.88
Formula	C₂₃H₂₁ClN₂O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1443437-74-8
PubChem ID	71681561
InChi Key	HERLZBNILRVHQN-UHFFFAOYSA-N
Smiles	O=C(N2CCCC(C(NC3=CC=C(Cl)C=C3)=O)C2)C1=CC=CC(C4=CC=CO4)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for CCG 203971

References are publications that support the biological activity of the product.

Bell Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents. Bioorg.Med.Chem.Lett. 2013 PMID: 23707258
Haak Targeting the myofibroblast genetic switch: inhibitors of myocardin-related transcription factor/serum response factor-regulated gene transcription prevent fibrosis in a murine model of skin injury. J.Pharmacol.Exp.Ther. 2014 PMID: 24706986
Michel Hope for disease-modifying treatment of systemic sclerosis/scleroderma. J.Pharmacol.Exp.Ther. 2014 PMID: 25053235

CCG 203971

Tocris Bioscience, part of Bio-Techne | Catalog # 5277

Key Product Details

Biological Activity for CCG 203971

Technical Data for CCG 203971

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for CCG 203971

Product Documents for CCG 203971

COA

Certificate of Analysis

SDS

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