CC 401 dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 6258

High affinity JNK inhibitor; also inhibits HCMV replication
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Key Product Details

Description

High affinity JNK inhibitor; also inhibits HCMV replication

View all JNK/c-jun Inhibitors »

Product Description

CC 401 dihydrochloride is a high affinity JNK inhibitor (Ki values are 25-50 nM). Inhibits JNK via competitive binding of the ATP-binding site of active, phosphorylated JNK. Exhibits > 40-fold selectivity for JNK over p38, ERK, IKK2, protein kinase C, Lck and ZAP70. Hepatoprotective. Also inhibits HCMV replication.

Product Specifications

Molecular Weight

461.39

Formula

C22H24N6O.2HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole dihydrochloride

CAS Number

2250025-96-6

PubChem ID

66576998

InChI Key

LDUPODIOUWRGCQ-UHFFFAOYSA-N

SMILES

N1(CCCCC1)CCOC2=CC=CC(C3=NNC4=CC=C(C5=NN=CN5)C=C34)=C2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 46.14 100
DMSO 46.14 100

Preparing Stock Solutions for CC 401 dihydrochloride

The following data is based on the product molecular weight 461.39

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.17 mL 10.84 mL 21.67 mL
5 mM 0.43 mL 2.17 mL 4.33 mL
10 mM 0.22 mL 1.08 mL 2.17 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for CC 401 dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CC 401 dihydrochloride

For research use only

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