CB-103 New

Name: CB-103
Brand: Tocris Bioscience
SKU: 9002

Tocris Bioscience, part of Bio-Techne | Catalog # 9002

COA / SDS

pan-Notch inhibitor; also inhibits differentiation of mural cells by downregulating Notch pathway.

Key Product Details

Description:	pan-Notch inhibitor; also inhibits differentiation of mural cells by downregulating Notch pathway.
Alternative Names:	Limantrafin
Chemical Name:	6-[4-(1,1-Dimethylethyl)phenoxy]-3-pyridinamine
Purity:	≥98% (HPLC)
Molecular Weight:	242.3

View Full Technical Details for CB-103

Technical Data
Citations

Biological Activity for CB-103

CB-103 is a highly specific protein-protein interaction (PPI) inhibitor that interferes with the interaction between the active intracellular domains of Notch receptors (NICD) and the CSL transcription factor complex. In combination with ICI 182,780 (Cat. No. 1047), CB-103 arrests the growth of mouse xenografts from a patient-derived endocrine-resistant model. Also displays potent tumor growth inhibition and delayed tumor relapse when CB-103 was combined with Taxol (Cat. No. 1097). CB-103 inhibits differentiation of mural cells by downregulating Notch pathway.CB-103 is orally bioavailable.

Technical Data for CB-103

M. Wt	242.3
Formula	C₁₅H₁₈N₂O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	218457-67-1
PubChem ID	2735289
InChi Key	WHIWGRCYMQLLAO-UHFFFAOYSA-N
Smiles	CC(C)(C)C1=CC=C(OC2=CC=C(N)C=N2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CB-103

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	24.23	100
	ethanol	24.23	100

Preparing Stock Solutions for CB-103

The following data is based on the product molecular weight 242.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.13 mL	20.64 mL	41.27 mL
5 mM	0.83 mL	4.13 mL	8.25 mL
10 mM	0.41 mL	2.06 mL	4.13 mL
50 mM	0.08 mL	0.41 mL	0.83 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for CB-103

References are publications that support the biological activity of the product.

Gastfriend Notch3 directs differentiation of brain mural cells from human pluripotent stem cell-derived neural crest. Sci.Adv. 2024 PMID: 38306433
Vigolo The efficacy of CB-103, a first-in-class transcriptional Notch inhibitor, in preclinical models of breast cancer. Cancers 2023 PMID: 37568775